Design and construction of poliovirus epitope expression vectors

K L Burke; J W Almond; D J Evans

doi:10.1385/0-89603-191-8:249

Design and construction of poliovirus epitope expression vectors

K L Burke, J W Almond, D J Evans

School of Biology

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We have developed the very safe and efficacious live-attenuated Sabin 1 poliovirus vaccine strain as a vehicle for the presentation of defined epitopes from foreign pathogens (1-3). Precise modification of the poliovirus capsid is made possible by the application of recombinant DNA technology to cloned cDNA copies of the viral genome, which are infectious for mammalian cells in culture (4).

Original language	English
Pages (from-to)	249-56
Number of pages	8
Journal	Methods in Molecular Biology
Volume	8
DOIs	https://doi.org/10.1385/0-89603-191-8:249
Publication status	Published - 1992

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10.1385/0-89603-191-8:249

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title = "Design and construction of poliovirus epitope expression vectors",

abstract = "We have developed the very safe and efficacious live-attenuated Sabin 1 poliovirus vaccine strain as a vehicle for the presentation of defined epitopes from foreign pathogens (1-3). Precise modification of the poliovirus capsid is made possible by the application of recombinant DNA technology to cloned cDNA copies of the viral genome, which are infectious for mammalian cells in culture (4).",

author = "Burke, {K L} and Almond, {J W} and Evans, {D J}",

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AU - Almond, J W

AU - Evans, D J

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AB - We have developed the very safe and efficacious live-attenuated Sabin 1 poliovirus vaccine strain as a vehicle for the presentation of defined epitopes from foreign pathogens (1-3). Precise modification of the poliovirus capsid is made possible by the application of recombinant DNA technology to cloned cDNA copies of the viral genome, which are infectious for mammalian cells in culture (4).

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DO - 10.1385/0-89603-191-8:249

M3 - Article

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SP - 249

EP - 256

JO - Methods in Molecular Biology

JF - Methods in Molecular Biology

ER -

Design and construction of poliovirus epitope expression vectors

Abstract

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