Depth-encoded optical coherence elastography for simultaneous volumetric imaging of two tissue faces

Qi Fang*, Luke Frewer, Philip Wijesinghe, Wes M. Allen, Lixin Chin, Juliana Hamzah, David D. Sampson, Andrea Curatolo, Brendan F.K. Ennedy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)
8 Downloads (Pure)

Abstract

Depth-encoded optical coherence elastography (OCE) enables simultaneous acquisition of two three-dimensional (3D) elastograms from opposite sides of a sample. By the choice of suitable path-length differences in each of two interferometers, the detected carrier frequencies are separated, allowing depth-ranging from each interferometer to be performed simultaneously using a single spectrometer. We demonstrate depth-encoded OCE on a silicone phantom and a freshly excised sample of mouse liver. This technique minimizes the required spectral detection hardware and halves the total scan time. Depth-encoded OCE may expedite clinical translation in time-sensitive applications requiring rapid 3D imaging of multiple tissue surfaces, such as tumor margin assessment in breast-conserving surgery.

Original languageEnglish
Pages (from-to)1233-1236
Number of pages4
JournalOptics Letters
Volume42
Issue number7
DOIs
Publication statusPublished - 17 Mar 2017

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