Delayed response task performance as a function of age in cynomolgus monkeys (Macaca fascicularis)

H. S. Darusman, J. Call, D. Sajuthi, S. J. Schapiro, A. Gjedde, O. Kalliokoski, J. Hau*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

We compared delayed response task performance in young, middle-aged, and old cynomolgus monkeys using three memory tests that have been used with non-human primates. Eighteen cynomolgus monkeys-6 young (4-9 years), 6 middle-aged (10-19 years), and 6 old (above 20 years)-were tested. In general, the old monkeys scored significantly worse than did the animals in the two other age groups. Longer delays between stimulus presentation and response increased the performance differences between the old and younger monkeys. The old monkeys in particular showed signs of impaired visuospatial memory and deteriorated memory consolidation and executive functioning. These results add to the body of evidence supporting the utility of Macaca fascicularis in studies of cognition and as a potential translational model for age-associated memory impairment/dementia-related disorders.

Original languageEnglish
Pages (from-to)259-267
Number of pages9
JournalPrimates
Volume55
Issue number2
DOIs
Publication statusPublished - Apr 2014

Keywords

  • Working memory
  • Aging
  • Non-human primate
  • Neurodegenerative disease
  • SHORT-TERM-MEMORY
  • CHIMPANZEES PAN-TROGLODYTES
  • CHILDREN HOMO-SAPIENS
  • ALZHEIMERS-DISEASE
  • RHESUS-MONKEYS
  • WORKING-MEMORY
  • COGNITIVE DEFICITS
  • PONGO-PYGMAEUS
  • GREAT APES
  • MODELS

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