Deep tissue contractility sensing with biointegrated microlasers

Marcel Schubert*, Lewis Woolfson, Isla R.M. Barnard, Amy M. Dorward, Becky Casement, Soraya Caixeiro, Andrew Morton, Gavin B. Robertson, Paul L. Appleton, Gareth B. Miles, Carl S. Tucker, Samantha J. Pitt, Malte C. Gather

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Characterizing single cell contractility in the beating heart is strongly limited by light scattering and extreme tissue dynamics. Here, we use tissue-integrated microlasers to measure contractility in live zebrafish and living myocardial slices at a depth several times deeper than multiphoton microscopy-based techniques.

Original languageEnglish
Title of host publicationNovel Techniques in Microscopy (NTM 2021)
Subtitle of host publicationProceedings Biophotonics Congress 2021, 12-16 April 2021, Washington, DC, United States
PublisherThe Optical Society
Number of pages2
ISBN (Electronic)9781557528209
ISBN (Print)9781943580859
Publication statusPublished - 2021
EventNovel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021 - Virtual, Online, United States
Duration: 12 Apr 202116 Apr 2021

Publication series

NameOptics InfoBase Conference Papers
ISSN (Print)2162-2701

Conference

ConferenceNovel Techniques in Microscopy, NTM 2021 - Part of Biophotonics Congress: Optics in the Life Sciences 2021
Country/TerritoryUnited States
CityVirtual, Online
Period12/04/2116/04/21

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