Cytoplasmic ezrin has prognostic significance for head and neck squamous cell carcinoma

R Madan, M Brandwein-Gensler, NF Schlecht, K Elias, E Gorbovitsky, TJ Belbin, R Mahood, D Breining, H Qian, G Childs, J Locker, R Smith, M Haigentz Jr, Francis James Gunn-Moore, MB Prystowsky

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)

Abstract

Background. Members of the ezrin-radixin-moesin (ERM) protein family regulate cellular shape, motility, and proliferation and potentially influence ability to metastasize. We investigated the correlation between ERM subcellular localization and survival in patients with squamous cell carcinoma (SCC).

Methods. Tissue microarrays (TMAs) were constructed from paraffin-embedded tissue, TMA sections were evaluated for ERM protein expression immunohistochemically. The results were compared across clinical and histopathologic variables.

Results. ERM staining results for 47 patients showed that cytoplasmic ERM expression was prevalent in tumors (> 92%). Whereas ezrin and moesin also localized to the membrane, only willin was found in the nucleus of tumors. Multivariable Cox regression analysis demonstrated that strong cytoplasmic ezrin expression was independently associated with poorer survival (p=.04, hazard ratio 1.82)

Conclusions. Both level of expression and subcellular localization of ERM proteins may be important indicators of clinical outcome in SCC. This pilot study justifies the need for an expanded validation study of ERM proteins and clinical outcome. (c) 2006 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)1018-1027
Number of pages10
JournalHead and Neck
Volume28(11)
DOIs
Publication statusPublished - Nov 2006

Keywords

  • head and neck neoplasms
  • immunohistochemistry
  • ezrin
  • moesin
  • survival analysis
  • NF2 TUMOR-SUPPRESSOR
  • GENE-EXPRESSION
  • MOLECULAR CLASSIFICATION
  • MICROARRAY ANALYSIS
  • CDNA MICROARRAYS
  • CANCER
  • MOESIN
  • IDENTIFICATION
  • MERLIN
  • METASTASIS

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