Cyclopropyl indolequinones: mechanistic probes for bioreductive anticancer drug action

C J Moody, C L Norton, A M Z Slawin, S Taylor

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A series of cyclopropyl indolequinones based on structures 5-7 was designed and synthesized to probe the structural features essential for bioreductive cytotoxicity. Ring opening of the cyclopropane ring under radical conditions was demonstrated to be mechanistically feasible, and related to the involvement of such one-electron processes in the cytotoxicity of cyclopropyl indolequinones under hypoxic conditions.

Original languageEnglish
Pages (from-to)611-634
Number of pages24
JournalAnti-Cancer Drug Design
Volume13
Issue number6
Publication statusPublished - Sept 1998

Keywords

  • cyclopropane
  • cytotoxic
  • hypoxia
  • indolequinone
  • DT-DIAPHORASE
  • AGENT EO9
  • CYCLOPROPAMITOSENES
  • REDUCTION

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