Cyclic dipeptides and the human microbiome: opportunities and challenges

Charlene Elizabeth Ogilvie, Clarissa Melo Czekster*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Citations (Scopus)
24 Downloads (Pure)

Abstract

Research into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis. Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs) into their surrounding environment. CDPs are ubiquitous signalling molecules that exhibit a wide range of biological activities, with particular relevance to human health due to their potential to act as microbiome modulators.
Original languageEnglish
Article number117372
Number of pages6
JournalBioorganic & Medicinal Chemistry
Volume90
Early online date19 Jun 2023
DOIs
Publication statusPublished - 15 Jul 2023

Keywords

  • Microbiome
  • Cyclic dipeptide
  • Diketopiperazine
  • Host-pathogen interaction

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