Cyclic dipeptides and the human microbiome: opportunities and challenges

Charlene Elizabeth Ogilvie; Clarissa Melo Czekster

doi:10.1016/j.bmc.2023.117372

Cyclic dipeptides and the human microbiome: opportunities and challenges

Charlene Elizabeth Ogilvie, Clarissa Melo Czekster^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

Abstract

Research into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis. Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs) into their surrounding environment. CDPs are ubiquitous signalling molecules that exhibit a wide range of biological activities, with particular relevance to human health due to their potential to act as microbiome modulators.

Original language	English
Article number	117372
Number of pages	6
Journal	Bioorganic & Medicinal Chemistry
Volume	90
Early online date	19 Jun 2023
DOIs	https://doi.org/10.1016/j.bmc.2023.117372
Publication status	Published - 15 Jul 2023

Keywords

Microbiome
Cyclic dipeptide
Diketopiperazine
Host-pathogen interaction

Access to Document

10.1016/j.bmc.2023.117372Licence: CC BY

Ogilvie_2023_BMC_Cyclic-dipeptides_CC
Copyright © 2023 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 3.48 MBLicence: CC BY

Clarissa Czekster ISSF3 round 6: Clarissa Czekster ISSF3 round 6
Melo Czekster, C. (PI)
The Wellcome Trust
1/04/21 → 31/03/22
Project: Standard

Cite this

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title = "Cyclic dipeptides and the human microbiome: opportunities and challenges",

abstract = "Research into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis. Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs) into their surrounding environment. CDPs are ubiquitous signalling molecules that exhibit a wide range of biological activities, with particular relevance to human health due to their potential to act as microbiome modulators.",

keywords = "Microbiome, Cyclic dipeptide, Diketopiperazine, Host-pathogen interaction",

author = "Ogilvie, {Charlene Elizabeth} and {Melo Czekster}, Clarissa",

note = "Funding: C.M.C. is funded by the Wellcome Trust (210486/Z/18/Z and [204821/Z/16/Z] to the University of St Andrews). C.E.O. is the recipient of a Carnegie Trust PhD studentship (PHD008520).",

year = "2023",

month = jul,

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doi = "10.1016/j.bmc.2023.117372",

language = "English",

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journal = "Bioorganic & Medicinal Chemistry",

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TY - JOUR

T1 - Cyclic dipeptides and the human microbiome

T2 - opportunities and challenges

AU - Ogilvie, Charlene Elizabeth

AU - Melo Czekster, Clarissa

N1 - Funding: C.M.C. is funded by the Wellcome Trust (210486/Z/18/Z and [204821/Z/16/Z] to the University of St Andrews). C.E.O. is the recipient of a Carnegie Trust PhD studentship (PHD008520).

PY - 2023/7/15

Y1 - 2023/7/15

N2 - Research into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis. Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs) into their surrounding environment. CDPs are ubiquitous signalling molecules that exhibit a wide range of biological activities, with particular relevance to human health due to their potential to act as microbiome modulators.

AB - Research into the human microbiome has implicated its constituents in a variety of non-communicable diseases, with certain microbes found to promote health and others leading to dysbiosis and pathogenesis. Microbes communicate and coordinate their behaviour through the secretion of small molecules, such as cyclic dipeptides (CDPs) into their surrounding environment. CDPs are ubiquitous signalling molecules that exhibit a wide range of biological activities, with particular relevance to human health due to their potential to act as microbiome modulators.

KW - Microbiome

KW - Cyclic dipeptide

KW - Diketopiperazine

KW - Host-pathogen interaction

U2 - 10.1016/j.bmc.2023.117372

DO - 10.1016/j.bmc.2023.117372

M3 - Review article

C2 - 37343497

SN - 0968-0896

VL - 90

JO - Bioorganic & Medicinal Chemistry

JF - Bioorganic & Medicinal Chemistry

M1 - 117372

ER -

Cyclic dipeptides and the human microbiome: opportunities and challenges

Abstract

Keywords

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Projects

Clarissa Czekster ISSF3 round 6: Clarissa Czekster ISSF3 round 6

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