Crystallization and preliminary X-ray diffraction analysis of Wza outer-membrane lipoprotein from Escherichia coli serotype O9a:K30

K Beis, J Nesper, C Whitfield, James Henderson Naismith

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11 Citations (Scopus)

Abstract

A novel integral membrane lipoprotein, Wza, from Escherichia coli serotype O9a:K30 has been purified and crystallized. Wza is required for the surface expression of the serotype K30 group 1 capsular polysaccharide of E. coli; closely related homologues are found in other bacteria that produce extracellular polysaccharides. The Wza crystals belong to the orthorhombic space group P2(1)2(1)2(1), with unit-cell parameters a=94.6, b=215.5, c=218.5 Angstrom. A data set to 3.0 Angstrom with 99.8% completeness and an R-merge of 10.5% has been collected from a single crystal.

Original languageEnglish
Pages (from-to)558-560
Number of pages3
JournalActa Crystallographica. Section D, Biological crystallography
Volume60
Issue number3
DOIs
Publication statusPublished - Mar 2004

Keywords

  • EXPRESSION
  • SURFACE
  • COMPLEX

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