Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Michael Fairhead, Kenneth A. Johnson, Thomas Kowatz, Stephen A. McMahon, Lester G. Carter, Muse Oke, Huanting Liu, James H. Naismith, Christopher F. van der Walle

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 angstrom crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

Original languageEnglish
Pages (from-to)1765-1767
Number of pages3
JournalChemical Communications
Issue number15
DOIs
Publication statusPublished - 21 Apr 2008

Keywords

  • DEMOSPONGE SUBERITES-DOMUNCULA
  • HUMAN PROCATHEPSIN L
  • IN-VITRO
  • BIOSILICA
  • FILAMENTS
  • SPICULES
  • BIOLOGY

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  • BBSRC BBS/B/14426: SPORT

    Naismith, J.

    BBSRC

    18/10/0430/04/12

    Project: Standard

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