Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Michael Fairhead; Kenneth A. Johnson; Thomas Kowatz; Stephen A. McMahon; Lester G. Carter; Muse Oke; Huanting Liu; James H. Naismith; Christopher F. van der Walle

doi:10.1039/b718264c

Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Michael Fairhead, Kenneth A. Johnson, Thomas Kowatz, Stephen A. McMahon, Lester G. Carter, Muse Oke, Huanting Liu, James H. Naismith, Christopher F. van der Walle

Research output: Contribution to journal › Article › peer-review

Abstract

Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 angstrom crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

Original language	English
Pages (from-to)	1765-1767
Number of pages	3
Journal	Chemical Communications
Issue number	15
DOIs	https://doi.org/10.1039/b718264c
Publication status	Published - 21 Apr 2008

Keywords

DEMOSPONGE SUBERITES-DOMUNCULA
HUMAN PROCATHEPSIN L
IN-VITRO
BIOSILICA
FILAMENTS
SPICULES
BIOLOGY

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10.1039/b718264c

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title = "Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras",

abstract = "Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 angstrom crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.",

keywords = "DEMOSPONGE SUBERITES-DOMUNCULA, HUMAN PROCATHEPSIN L, IN-VITRO, BIOSILICA, FILAMENTS, SPICULES, BIOLOGY",

author = "Michael Fairhead and Johnson, {Kenneth A.} and Thomas Kowatz and McMahon, {Stephen A.} and Carter, {Lester G.} and Muse Oke and Huanting Liu and Naismith, {James H.} and {van der Walle}, {Christopher F.}",

year = "2008",

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day = "21",

doi = "10.1039/b718264c",

language = "English",

pages = "1765--1767",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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AU - Fairhead, Michael

AU - Johnson, Kenneth A.

AU - Kowatz, Thomas

AU - McMahon, Stephen A.

AU - Carter, Lester G.

AU - Oke, Muse

AU - Liu, Huanting

AU - Naismith, James H.

AU - van der Walle, Christopher F.

PY - 2008/4/21

Y1 - 2008/4/21

N2 - Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 angstrom crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

AB - Cathepsin L mutants with the ability to condense silica from solution have been generated and a 1.5 angstrom crystal structure of one of these chimeras allows us to rationalise the catalytic mechanism of silicic acid condensation.

KW - DEMOSPONGE SUBERITES-DOMUNCULA

KW - HUMAN PROCATHEPSIN L

KW - IN-VITRO

KW - BIOSILICA

KW - FILAMENTS

KW - SPICULES

KW - BIOLOGY

UR - http://www.scopus.com/inward/record.url?scp=41549158169&partnerID=8YFLogxK

U2 - 10.1039/b718264c

DO - 10.1039/b718264c

M3 - Article

SN - 1359-7345

SP - 1765

EP - 1767

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Abstract

Keywords

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BBSRC BBS/B/14426: SPORT

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Crystal structure and silica condensing activities of silicatein alpha-cathepsin L chimeras

Abstract

Keywords

Access to Document

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Fingerprint

Projects

BBSRC BBS/B/14426: SPORT

Cite this