Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates

Vincent Roy; Hiroki Kumamoto; Sabine Berteina-Raboin; Steven Patrick Nolan; Dimitri Topalis; Dominique Deville-Bonne; Jan Balzarini; Johan Neyts; Gracelia Andrei; Robert Snoeck; Luigi A Agrofoglio

doi:10.1080/15257770701534196

Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates

Vincent Roy, Hiroki Kumamoto, Sabine Berteina-Raboin, Steven Patrick Nolan, Dimitri Topalis, Dominique Deville-Bonne, Jan Balzarini, Johan Neyts, Gracelia Andrei, Robert Snoeck, Luigi A Agrofoglio

Research output: Contribution to journal › Article › peer-review

Abstract

With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad junctional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.

Original language	English
Pages (from-to)	1399-1402
Number of pages	4
Journal	Nucleosides, Nucleotides and Nucleic Acids
Volume	26
Issue number	10-12
DOIs	https://doi.org/10.1080/15257770701534196
Publication status	Published - Oct 2007

Keywords

acyclic nucleoside phosphonate
cidofovir
cross-metathesis
RING-CLOSING METATHESIS
OLEFIN METATHESIS
CATALYSTS
EFFICIENT

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10.1080/15257770701534196

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abstract = "With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad junctional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.",

keywords = "acyclic nucleoside phosphonate, cidofovir, cross-metathesis, RING-CLOSING METATHESIS, OLEFIN METATHESIS, CATALYSTS, EFFICIENT",

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language = "English",

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T1 - Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates

AU - Roy, Vincent

AU - Kumamoto, Hiroki

AU - Berteina-Raboin, Sabine

AU - Nolan, Steven Patrick

AU - Topalis, Dimitri

AU - Deville-Bonne, Dominique

AU - Balzarini, Jan

AU - Neyts, Johan

AU - Andrei, Gracelia

AU - Snoeck, Robert

AU - Agrofoglio, Luigi A

PY - 2007/10

Y1 - 2007/10

N2 - With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad junctional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.

AB - With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad junctional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.

KW - acyclic nucleoside phosphonate

KW - cidofovir

KW - cross-metathesis

KW - RING-CLOSING METATHESIS

KW - OLEFIN METATHESIS

KW - CATALYSTS

KW - EFFICIENT

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DO - 10.1080/15257770701534196

M3 - Article

SN - 1525-7770

VL - 26

SP - 1399

EP - 1402

JO - Nucleosides, Nucleotides and Nucleic Acids

JF - Nucleosides, Nucleotides and Nucleic Acids

IS - 10-12

ER -

Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates

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