Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates

Vincent Roy, Hiroki Kumamoto, Sabine Berteina-Raboin, Steven Patrick Nolan, Dimitri Topalis, Dominique Deville-Bonne, Jan Balzarini, Johan Neyts, Gracelia Andrei, Robert Snoeck, Luigi A Agrofoglio

Research output: Contribution to journalArticlepeer-review

Abstract

With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad junctional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.

Original languageEnglish
Pages (from-to)1399-1402
Number of pages4
JournalNucleosides, Nucleotides and Nucleic Acids
Volume26
Issue number10-12
DOIs
Publication statusPublished - Oct 2007

Keywords

  • acyclic nucleoside phosphonate
  • cidofovir
  • cross-metathesis
  • RING-CLOSING METATHESIS
  • OLEFIN METATHESIS
  • CATALYSTS
  • EFFICIENT

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