TY - JOUR
T1 - Cross-Metathesis Mediated Synthesis of New Acyclic Nucleoside Phosphonates
AU - Roy, Vincent
AU - Kumamoto, Hiroki
AU - Berteina-Raboin, Sabine
AU - Nolan, Steven Patrick
AU - Topalis, Dimitri
AU - Deville-Bonne, Dominique
AU - Balzarini, Jan
AU - Neyts, Johan
AU - Andrei, Gracelia
AU - Snoeck, Robert
AU - Agrofoglio, Luigi A
PY - 2007/10
Y1 - 2007/10
N2 - With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad junctional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.
AB - With the commercial availability of well-defined ruthenium metathesis catalysts which combine high stability and broad junctional group compatibility, olefin metathesis is now routinely integrated in various syntheses. We will report here the overwhelming power and scope of cross-metathesis in the area of new acyclic nucleoside phosphonates. Scope and limitations of this approach, and especially the E/Z stereocontrol, are discussed on selected examples from our drug discovery group.
KW - acyclic nucleoside phosphonate
KW - cidofovir
KW - cross-metathesis
KW - RING-CLOSING METATHESIS
KW - OLEFIN METATHESIS
KW - CATALYSTS
KW - EFFICIENT
UR - http://www.scopus.com/inward/record.url?scp=36949034699&partnerID=8YFLogxK
U2 - 10.1080/15257770701534196
DO - 10.1080/15257770701534196
M3 - Article
SN - 1525-7770
VL - 26
SP - 1399
EP - 1402
JO - Nucleosides, Nucleotides and Nucleic Acids
JF - Nucleosides, Nucleotides and Nucleic Acids
IS - 10-12
ER -