Abstract
A series of well-defined, air- and moisture-stable (NHC)Pd(allyl)Cl (NHC = N-heterocyclic carbene) complexes has been used in several catalytic reactions: Suzuki-Miyaura cross-coupling, catalytic dehalogenation of aryl halides, and aryl amination. The scope of the three processes using various substrates was examined. A general system involving the use of (IPr)Pd(allyl)Cl as catalyst and (NaOBu)-Bu-t as base has proven to be highly active for the Suzuki-Miyaura cross-coupling of activated and unactivated aryl chlorides and bromides, for the catalytic dehalogenation of aryl chlorides, and for the catalytic aryl amination of aryl triflates. All reactions proceed in short reaction times and at mild temperatures. The system has also proven to be compatible with the microwave-assisted Suzuki-Miyaura cross-coupling and catalytic dehalogenation processes, affording yields similar to those of the conventionally heated analogous reactions.
Original language | English |
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Pages (from-to) | 3173-3180 |
Number of pages | 8 |
Journal | The Journal of Organic Chemistry |
Volume | 69 |
Issue number | 9 |
DOIs | |
Publication status | Published - 30 Apr 2004 |
Keywords
- N-HETEROCYCLIC CARBENE
- PALLADIUM/IMIDAZOLIUM CHLORIDE SYSTEM
- NITROGEN BOND FORMATION
- ARYL CHLORIDES
- GRIGNARD-REAGENTS
- ROOM-TEMPERATURE
- ORGANIC HALIDES
- ORGANOBORON COMPOUNDS
- (NHC)PD(ALLYL)CL NHC
- ARYLBORONIC ACIDS