Coumarin-oxadiazole derivatives: synthesis and pharmacological properties

Nurhayatun S. Abdul Razak; Joazaizulfazli Jamalis; Subhash Chander; Roswanira Abdul Wahab; Deepak P. Bhagwat; Terry K. Smith; Murugesan Sankaranarayanan

doi:10.2174/1570193x16666191029111051

Coumarin-oxadiazole derivatives: synthesis and pharmacological properties

Nurhayatun S. Abdul Razak, Joazaizulfazli Jamalis, Subhash Chander, Roswanira Abdul Wahab, Deepak P. Bhagwat, Terry K. Smith, Murugesan Sankaranarayanan

Research output: Contribution to journal › Review article › peer-review

Abstract

Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper.

Original language	English
Pages (from-to)	780-794
Number of pages	15
Journal	Mini-Reviews in Organic Chemistry
Volume	17
Issue number	7
DOIs	https://doi.org/10.2174/1570193x16666191029111051
Publication status	Published - 9 Oct 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Biological activities
Coumarin-oxadiazole
Coumarins
Drugs
Oxadiazoles
Synthesis

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title = "Coumarin-oxadiazole derivatives: synthesis and pharmacological properties",

abstract = "Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper.",

keywords = "Biological activities, Coumarin-oxadiazole, Coumarins, Drugs, Oxadiazoles, Synthesis",

author = "\{Abdul Razak\}, \{Nurhayatun S.\} and Joazaizulfazli Jamalis and Subhash Chander and Wahab, \{Roswanira Abdul\} and Bhagwat, \{Deepak P.\} and Smith, \{Terry K.\} and Murugesan Sankaranarayanan",

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doi = "10.2174/1570193x16666191029111051",

language = "English",

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T1 - Coumarin-oxadiazole derivatives

T2 - synthesis and pharmacological properties

AU - Abdul Razak, Nurhayatun S.

AU - Jamalis, Joazaizulfazli

AU - Chander, Subhash

AU - Wahab, Roswanira Abdul

AU - Bhagwat, Deepak P.

AU - Smith, Terry K.

AU - Sankaranarayanan, Murugesan

PY - 2020/10/9

Y1 - 2020/10/9

N2 - Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper.

AB - Coumarin and oxadiazole moieties ubiquitously occur in a wide range of natural products and are valued for their varied and beneficial pharmacological activities. Herein, this review focuses on various documented techniques used by researchers to synthesize an assortment of biologically active coumarin-oxadiazole scaffolds. Also, the common techniques discussed are used to establish the wide-range of biological activities of the synthesized coumarin and oxadiozole derivatives, including; antioxidant, anthelmintic, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, cytotoxicity and anticonvulsant. Additionally, the current, well-established drugs synthesized using coumarin-oxadiazole scaffolds are typically dispensed in regular clinical practice are also highlighted in this review paper.

KW - Biological activities

KW - Coumarin-oxadiazole

KW - Coumarins

KW - Drugs

KW - Oxadiazoles

KW - Synthesis

UR - https://www.scopus.com/pages/publications/85090766374

U2 - 10.2174/1570193x16666191029111051

DO - 10.2174/1570193x16666191029111051

M3 - Review article

SN - 1570-193X

VL - 17

SP - 780

EP - 794

JO - Mini-Reviews in Organic Chemistry

JF - Mini-Reviews in Organic Chemistry

IS - 7

ER -

Coumarin-oxadiazole derivatives: synthesis and pharmacological properties

Abstract

UN SDGs

Keywords

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