Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols

Michael Trose; Faima Lazreg; Mathieu Lesieur; Catherine S.J. Cazin

doi:10.1021/acs.joc.5b01382

Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols

Michael Trose, Faima Lazreg, Mathieu Lesieur, Catherine S.J. Cazin

Research output: Contribution to journal › Article › peer-review

Abstract

The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper–NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than previously reported methods.

Original language	English
Journal	The Journal of Organic Chemistry
Volume	Article ASAP
Early online date	1 Oct 2015
DOIs	https://doi.org/10.1021/acs.joc.5b01382
Publication status	Published - 2015

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10.1021/acs.joc.5b01382

Trose_2015_JOC_Copper_AM
© 2015 American Chemical Society. This document is the Accepted Manuscript version of a Published Work that appeared in final form in Journal of Organic Chemistry, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://dx.doi.org/10.1021/acs.joc.5b01382
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@article{12cb9e5866b64f019dfbe647d3b8ee3b,

title = "Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols",

abstract = "The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper–NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than previously reported methods.",

author = "Michael Trose and Faima Lazreg and Mathieu Lesieur and Cazin, {Catherine S.J.}",

note = "The authors gratefully acknowledge the Royal Society (University research Fellowship to C.S.J.C) for funding. ",

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language = "English",

volume = "Article ASAP",

journal = "The Journal of Organic Chemistry",

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T1 - Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols

AU - Trose, Michael

AU - Lazreg, Faima

AU - Lesieur, Mathieu

AU - Cazin, Catherine S.J.

N1 - The authors gratefully acknowledge the Royal Society (University research Fellowship to C.S.J.C) for funding.

PY - 2015

Y1 - 2015

N2 - The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper–NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than previously reported methods.

AB - The reaction between nitriles and aminoalcohols to access 2-substituted oxazolines was investigated. Using copper–NHC complexes, various nitriles were successfully converted into the corresponding oxazolines, under milder and less wasteful conditions than previously reported methods.

UR - http://pubs.acs.org/doi/suppl/10.1021/acs.joc.5b01382q

U2 - 10.1021/acs.joc.5b01382

DO - 10.1021/acs.joc.5b01382

M3 - Article

SN - 0022-3263

VL - Article ASAP

JO - The Journal of Organic Chemistry

JF - The Journal of Organic Chemistry

ER -

Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols

Abstract

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Catalytic C-H bond functionalisation: Catalytic C-H bond functionalisation

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Copper N-heterocyclic carbene complexes as active catalysts for the synthesis of 2-substituted oxazolines from nitriles and aminoalcohols

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Catalytic C-H bond functionalisation: Catalytic C-H bond functionalisation

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