Copper-catalyzed asymmetric sp3 C-H arylation of tetrahydroisoquinoline mediated by a visible light photoredox catalyst

Pierre Querard, Inna Perepichka, Eli Zysman-Colman, Chao-Jun Li

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

This report describes a highly enantioselective oxidative sp3 C-H arylation of N-aryltetrahydroisoquinolines (THIQs) through a dual catalysis platform. The combination of the photoredox catalyst, [Ir(ppy)2(dtbbpy)]PF6, and chiral copper catalysts provide a mild and highly effective sp3 C-H asymmetric arylation of THIQs.

Original languageEnglish
Pages (from-to)2636-2643
Number of pages8
JournalBeilstein Journal of Organic Chemistry
Volume12
DOIs
Publication statusPublished - 6 Dec 2016

Keywords

  • C-H arylation
  • Copper catalyst
  • Enantioselectivity
  • Visible light

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