Control by the brain of vitamin A homeostasis

Peter I. Imoesi; Cristian M. Olarte-Sánchez; Lorenzo Croce; William S. Blaner; Peter J. Morgan; Lora Heisler; Peter McCaffery

doi:10.1016/j.isci.2023.107373

Control by the brain of vitamin A homeostasis

Peter I. Imoesi, Cristian M. Olarte-Sánchez, Lorenzo Croce, William S. Blaner, Peter J. Morgan, Lora Heisler, Peter McCaffery^*

^*Corresponding author for this work

School of Medicine

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Abstract

Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, regulates vitamin A levels in the liver and circulation. Vitamin A in the form of retinol or retinoic acid was stereotactically injected into the 3^rd ventricle of the rat brain. Alternatively, retinoids in the mouse hypothalamus were altered through retinol-binding protein 4 (Rbp4) gene knockdown. This led to rapid change in the liver proteins controlling vitamin A homeostasis as well as vitamin A itself in liver and the circulation. Prolonged disruption of Rbp4 in the region of the arcuate nucleus of the mouse hypothalamus altered retinol levels in the liver. This supports the concept that the brain may sense retinoids and influence whole-body vitamin A homeostasis with a possible “vitaminostatic” role.

Original language	English
Article number	107373
Number of pages	18
Journal	iScience
Volume	26
Issue number	8
Early online date	5 Aug 2023
DOIs	https://doi.org/10.1016/j.isci.2023.107373
Publication status	Published - 18 Aug 2023

Keywords

Biological sciences
Endocrinology
Natural sciences
Neuroscience
Physiology

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Copyright © 2023 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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title = "Control by the brain of vitamin A homeostasis",

abstract = "Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, regulates vitamin A levels in the liver and circulation. Vitamin A in the form of retinol or retinoic acid was stereotactically injected into the 3rd ventricle of the rat brain. Alternatively, retinoids in the mouse hypothalamus were altered through retinol-binding protein 4 (Rbp4) gene knockdown. This led to rapid change in the liver proteins controlling vitamin A homeostasis as well as vitamin A itself in liver and the circulation. Prolonged disruption of Rbp4 in the region of the arcuate nucleus of the mouse hypothalamus altered retinol levels in the liver. This supports the concept that the brain may sense retinoids and influence whole-body vitamin A homeostasis with a possible “vitaminostatic” role.",

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author = "Imoesi, {Peter I.} and Olarte-S{\'a}nchez, {Cristian M.} and Lorenzo Croce and Blaner, {William S.} and Morgan, {Peter J.} and Lora Heisler and Peter McCaffery",

note = "Funding: PJMc acknowledges funding from the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) grant number BB/T00875X/1 , the University of Aberdeen Elphinstone PhD Scholarship , Sir Richard Stapley Educational Trust , and home sponsor for PII. PJM acknowledges support from the Rural and Environment Science and Analytical Services Division (RESAS) division of the Scottish Government. LKH acknowledges funding from the BBSRC ( BB/R01857X/1 ; BBV016849/1 ). Further support was received from BBSRC grant BB/P004806/1 . Also acknowledged is funding from an MRC Discovery award ( MRC/PC/15077 ). ",

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AU - Imoesi, Peter I.

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AU - Croce, Lorenzo

AU - Blaner, William S.

AU - Morgan, Peter J.

AU - Heisler, Lora

AU - McCaffery, Peter

N1 - Funding: PJMc acknowledges funding from the UKRI Biotechnology and Biological Sciences Research Council (BBSRC) grant number BB/T00875X/1 , the University of Aberdeen Elphinstone PhD Scholarship , Sir Richard Stapley Educational Trust , and home sponsor for PII. PJM acknowledges support from the Rural and Environment Science and Analytical Services Division (RESAS) division of the Scottish Government. LKH acknowledges funding from the BBSRC ( BB/R01857X/1 ; BBV016849/1 ). Further support was received from BBSRC grant BB/P004806/1 . Also acknowledged is funding from an MRC Discovery award ( MRC/PC/15077 ).

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N2 - Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, regulates vitamin A levels in the liver and circulation. Vitamin A in the form of retinol or retinoic acid was stereotactically injected into the 3rd ventricle of the rat brain. Alternatively, retinoids in the mouse hypothalamus were altered through retinol-binding protein 4 (Rbp4) gene knockdown. This led to rapid change in the liver proteins controlling vitamin A homeostasis as well as vitamin A itself in liver and the circulation. Prolonged disruption of Rbp4 in the region of the arcuate nucleus of the mouse hypothalamus altered retinol levels in the liver. This supports the concept that the brain may sense retinoids and influence whole-body vitamin A homeostasis with a possible “vitaminostatic” role.

AB - Vitamin A is a micronutrient essential for vertebrate animals maintained in homeostatic balance in the body; however, little is known about the control of this balance. This study investigated whether the hypothalamus, a key integrative brain region, regulates vitamin A levels in the liver and circulation. Vitamin A in the form of retinol or retinoic acid was stereotactically injected into the 3rd ventricle of the rat brain. Alternatively, retinoids in the mouse hypothalamus were altered through retinol-binding protein 4 (Rbp4) gene knockdown. This led to rapid change in the liver proteins controlling vitamin A homeostasis as well as vitamin A itself in liver and the circulation. Prolonged disruption of Rbp4 in the region of the arcuate nucleus of the mouse hypothalamus altered retinol levels in the liver. This supports the concept that the brain may sense retinoids and influence whole-body vitamin A homeostasis with a possible “vitaminostatic” role.

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KW - Endocrinology

KW - Natural sciences

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Control by the brain of vitamin A homeostasis

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