Comprehensive survey of developmental genes in the pea aphid, Acyrthosiphon pisum: frequent lineage-specific duplications and losses of developmental genes

S. Shigenobu, R. D. Bickel, J. A. Brisson, T. Butts, C-C. Chang, O. Christiaens, G. K. Davis, E. J. Duncan, David Ellard Keith Ferrier, M. Iga, R. Janssen, G. -W. Lin, H. -L. Lu, A. P. McGregor, T. Miura, G. Smagghe, J. M. Smith, M. van der Zee, R. A. Velarde, M. J. WilsonP. K. Dearden, D. L. Stern

Research output: Contribution to journalArticlepeer-review

54 Citations (Scopus)

Abstract

Aphids exhibit unique attributes, such as polyphenisms and specialized cells to house endosymbionts, that make them an interesting system for studies at the interface of ecology, evolution and development. Here we present a comprehensive characterization of the developmental genes in the pea aphid, Acyrthosiphon pisum, and compare our results to other sequenced insects. We investigated genes involved in fundamental developmental processes such as establishment of the body plan and organogenesis, focusing on transcription factors and components of signalling pathways. We found that most developmental genes were well conserved in the pea aphid, although many lineage-specific gene duplications and gene losses have occurred in several gene families. In particular, genetic components of transforming growth factor beta (TGF beta) Wnt, JAK/STAT (Janus kinase/signal transducer and activator of transcription) and EGF (Epidermal Growth Factor) pathways appear to have been significantly modified in the pea aphid.

Original languageEnglish
Pages (from-to)47-62
Number of pages16
JournalInsect Molecular Biology
Volume19
DOIs
Publication statusPublished - 10 Mar 2010

Keywords

  • aphid
  • genome analysis
  • signalling pathway
  • development
  • hemimetabolous insect
  • polyphenism
  • symbiosis
  • BEETLE TRIBOLIUM-CASTANEUM
  • GERM-CELL SPECIFICATION
  • ASYMMETRIC LOCALIZATION
  • NEMATOSTELLA-VECTENSIS
  • WING POLYMORPHISM
  • PATTERN-FORMATION
  • DROSOPHILA
  • EXPRESSION
  • SEGMENTATION
  • INSECT

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