Composition and dynamics of the eukaryotic replisome: a brief overview

Research output: Chapter in Book/Report/Conference proceedingChapter

9 Citations (Scopus)

Abstract

High-fidelity chromosomal DNA replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In eukaryotic cells, around 40-50 distinct conserved polypeptides are essential for chromosome replication, the majority of which are themselves component parts of a series of elaborate molecular machines that comprise the replication apparatus or replisome. How these complexes are assembled, what structures they adopt, how they perform their functions, and how those functions are regulated, are key questions for understanding how genome duplication occurs. Here I present a brief overview of current knowledge of the dynamic molecular events underlying chromosomal DNA replication in eukaryotic cells and how these events are regulated.
Original languageEnglish
Title of host publicationThe eukaryotic replisome
Subtitle of host publicationa guide to protein structure and function
EditorsStuart MacNeill
Place of PublicationDordrecht
PublisherSpringer
Pages1-17
Number of pages17
ISBN (Electronic)9789400745728
ISBN (Print)9789400745711
DOIs
Publication statusPublished - 2012

Publication series

NameSubcellular Biochemistry
Volume62
ISSN (Print) 306-0225

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