TY - CHAP
T1 - Composition and dynamics of the eukaryotic replisome
T2 - a brief overview
AU - MacNeill, Stuart
PY - 2012
Y1 - 2012
N2 - High-fidelity chromosomal DNA replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In eukaryotic cells, around 40-50 distinct conserved polypeptides are essential for chromosome replication, the majority of which are themselves component parts of a series of elaborate molecular machines that comprise the replication apparatus or replisome. How these complexes are assembled, what structures they adopt, how they perform their functions, and how those functions are regulated, are key questions for understanding how genome duplication occurs. Here I present a brief overview of current knowledge of the dynamic molecular events underlying chromosomal DNA replication in eukaryotic cells and how these events are regulated.
AB - High-fidelity chromosomal DNA replication is vital for maintaining the integrity of the genetic material in all forms of cellular life. In eukaryotic cells, around 40-50 distinct conserved polypeptides are essential for chromosome replication, the majority of which are themselves component parts of a series of elaborate molecular machines that comprise the replication apparatus or replisome. How these complexes are assembled, what structures they adopt, how they perform their functions, and how those functions are regulated, are key questions for understanding how genome duplication occurs. Here I present a brief overview of current knowledge of the dynamic molecular events underlying chromosomal DNA replication in eukaryotic cells and how these events are regulated.
UR - https://link.springer.com/book/10.1007/978-94-007-4572-8
U2 - 10.1007/978-94-007-4572-8_1
DO - 10.1007/978-94-007-4572-8_1
M3 - Chapter
SN - 9789400745711
T3 - Subcellular Biochemistry
SP - 1
EP - 17
BT - The eukaryotic replisome
A2 - MacNeill, Stuart
PB - Springer
CY - Dordrecht
ER -