Complete sequence and organization of pBtoxis, the toxin-coding plasmid of Bacillus thuringiensis subsp israelensis

C Berry*, S O'Neil, E Ben-Dov, AF Jones, L Murphy, MA Quail, MTG Holden, D Harris, A Zaritsky, J Parkhill

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

263 Citations (Scopus)

Abstract

The entire 127,923-bp sequence of the toxin-encoding plasmid pBtoxis from Bacillus thuringiensis subsp. israelensis is presented and analyzed. In addition to the four known Cry and two known Cyt toxins, a third Cyt-type sequence was found with an additional C-terminal domain previously unseen in such proteins. Many plasmid-encoded genes could be involved in several functions other than toxin production. The most striking of these are several genes potentially affecting host sporulation and germination and a set of genes for the production and export of a peptide antibiotic.

Original languageEnglish
Pages (from-to)5082-5095
Number of pages14
JournalApplied and Environmental Microbiology
Volume68
Issue number10
DOIs
Publication statusPublished - Oct 2002

Keywords

  • PEPTIDE ANTIBIOTIC AS-48
  • NUCLEOTIDE-SEQUENCE
  • SPORE GERMINATION
  • TRANSCRIPTIONAL REGULATION
  • ENTEROCOCCUS-FAECALIS
  • CRYSTAL PROTEINS
  • ESCHERICHIA-COLI
  • RESTRICTION MAP
  • MOSQUITO LARVAE
  • RNA-POLYMERASE

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