Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

WH Wilson; DC Schroeder; MJ Allen; MTG Holden; J Parkhill; BG Barrell; C Churcher; N Harnlin; K Mungall; H Norbertczak; MA Quail; C Price; E Rabbinowitsch; D Walker; M Craigon; D Roy; P Ghazal

doi:10.1126/science.1113109

Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

WH Wilson^*, DC Schroeder, MJ Allen, MTG Holden, J Parkhill, BG Barrell, C Churcher, N Harnlin, K Mungall, H Norbertczak, MA Quail, C Price, E Rabbinowitsch, D Walker, M Craigon, D Roy, P Ghazal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

Original language	English
Pages (from-to)	1090-1092
Number of pages	3
Journal	Science
Volume	309
Issue number	5737
DOIs	https://doi.org/10.1126/science.1113109
Publication status	Published - 12 Aug 2005

Keywords

EMILIANIA-HUXLEYI
CELL-DEATH
PHOSPHATE TRANSPORTER
VIRUSES
APOPTOSIS
CERAMIDE
PHYCODNAVIRIDAE
PHYTOPLANKTON
LIMITATION
NITROGEN

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1126/science.1113109

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Wilson, WH., Schroeder, DC., Allen, MJ., Holden, MTG., Parkhill, J., Barrell, BG., Churcher, C., Harnlin, N., Mungall, K., Norbertczak, H., Quail, MA., Price, C., Rabbinowitsch, E., Walker, D., Craigon, M., Roy, D., & Ghazal, P. (2005). Complete genome sequence and lytic phase transcription profile of a Coccolithovirus. Science, 309(5737), 1090-1092. https://doi.org/10.1126/science.1113109

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title = "Complete genome sequence and lytic phase transcription profile of a Coccolithovirus",

abstract = "The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65\% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.",

keywords = "EMILIANIA-HUXLEYI, CELL-DEATH, PHOSPHATE TRANSPORTER, VIRUSES, APOPTOSIS, CERAMIDE, PHYCODNAVIRIDAE, PHYTOPLANKTON, LIMITATION, NITROGEN",

author = "WH Wilson and DC Schroeder and MJ Allen and MTG Holden and J Parkhill and BG Barrell and C Churcher and N Harnlin and K Mungall and H Norbertczak and MA Quail and C Price and E Rabbinowitsch and D Walker and M Craigon and D Roy and P Ghazal",

year = "2005",

month = aug,

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doi = "10.1126/science.1113109",

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volume = "309",

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Wilson, WH, Schroeder, DC, Allen, MJ, Holden, MTG, Parkhill, J, Barrell, BG, Churcher, C, Harnlin, N, Mungall, K, Norbertczak, H, Quail, MA, Price, C, Rabbinowitsch, E, Walker, D, Craigon, M, Roy, D & Ghazal, P 2005, 'Complete genome sequence and lytic phase transcription profile of a Coccolithovirus', Science, vol. 309, no. 5737, pp. 1090-1092. https://doi.org/10.1126/science.1113109

TY - JOUR

T1 - Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

AU - Wilson, WH

AU - Schroeder, DC

AU - Allen, MJ

AU - Holden, MTG

AU - Parkhill, J

AU - Barrell, BG

AU - Churcher, C

AU - Harnlin, N

AU - Mungall, K

AU - Norbertczak, H

AU - Quail, MA

AU - Price, C

AU - Rabbinowitsch, E

AU - Walker, D

AU - Craigon, M

AU - Roy, D

AU - Ghazal, P

PY - 2005/8/12

Y1 - 2005/8/12

N2 - The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

AB - The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

KW - EMILIANIA-HUXLEYI

KW - CELL-DEATH

KW - PHOSPHATE TRANSPORTER

KW - VIRUSES

KW - APOPTOSIS

KW - CERAMIDE

KW - PHYCODNAVIRIDAE

KW - PHYTOPLANKTON

KW - LIMITATION

KW - NITROGEN

UR - https://www.scopus.com/pages/publications/23644461765

U2 - 10.1126/science.1113109

DO - 10.1126/science.1113109

M3 - Article

SN - 0036-8075

VL - 309

SP - 1090

EP - 1092

JO - Science

JF - Science

IS - 5737

ER -

Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

Abstract

Keywords

UN SDGs

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