Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

WH Wilson; DC Schroeder; MJ Allen; MTG Holden; J Parkhill; BG Barrell; C Churcher; N Harnlin; K Mungall; H Norbertczak; MA Quail; C Price; E Rabbinowitsch; D Walker; M Craigon; D Roy; P Ghazal

doi:10.1126/science.1113109

Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

WH Wilson^*
, DC Schroeder
, MJ Allen
, MTG Holden
, J Parkhill
, BG Barrell
, C Churcher
, N Harnlin
, K Mungall
, H Norbertczak
, MA Quail
, C Price
, E Rabbinowitsch
, D Walker
, M Craigon
, D Roy
, P Ghazal

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

Original language	English
Pages (from-to)	1090-1092
Number of pages	3
Journal	Science
Volume	309
Issue number	5737
DOIs	https://doi.org/10.1126/science.1113109
Publication status	Published - 12 Aug 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Keywords

EMILIANIA-HUXLEYI
CELL-DEATH
PHOSPHATE TRANSPORTER
VIRUSES
APOPTOSIS
CERAMIDE
PHYCODNAVIRIDAE
PHYTOPLANKTON
LIMITATION
NITROGEN

Access to Document

10.1126/science.1113109

Handle.net

Persistent link to portal record

Cite this

Wilson, WH., Schroeder, DC., Allen, MJ., Holden, MTG., Parkhill, J., Barrell, BG., Churcher, C., Harnlin, N., Mungall, K., Norbertczak, H., Quail, MA., Price, C., Rabbinowitsch, E., Walker, D., Craigon, M., Roy, D., & Ghazal, P. (2005). Complete genome sequence and lytic phase transcription profile of a Coccolithovirus. Science, 309(5737), 1090-1092. https://doi.org/10.1126/science.1113109

@article{0c1fd761803143bb9dc632a6e0e41db4,

title = "Complete genome sequence and lytic phase transcription profile of a Coccolithovirus",

abstract = "The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65\% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.",

keywords = "EMILIANIA-HUXLEYI, CELL-DEATH, PHOSPHATE TRANSPORTER, VIRUSES, APOPTOSIS, CERAMIDE, PHYCODNAVIRIDAE, PHYTOPLANKTON, LIMITATION, NITROGEN",

author = "WH Wilson and DC Schroeder and MJ Allen and MTG Holden and J Parkhill and BG Barrell and C Churcher and N Harnlin and K Mungall and H Norbertczak and MA Quail and C Price and E Rabbinowitsch and D Walker and M Craigon and D Roy and P Ghazal",

year = "2005",

month = aug,

day = "12",

doi = "10.1126/science.1113109",

language = "English",

volume = "309",

pages = "1090--1092",

journal = "Science",

issn = "0036-8075",

publisher = "American Association for the Advancement of Science",

number = "5737",

}

Wilson, WH, Schroeder, DC, Allen, MJ, Holden, MTG, Parkhill, J, Barrell, BG, Churcher, C, Harnlin, N, Mungall, K, Norbertczak, H, Quail, MA, Price, C, Rabbinowitsch, E, Walker, D, Craigon, M, Roy, D & Ghazal, P 2005, 'Complete genome sequence and lytic phase transcription profile of a Coccolithovirus', Science, vol. 309, no. 5737, pp. 1090-1092. https://doi.org/10.1126/science.1113109

TY - JOUR

T1 - Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

AU - Wilson, WH

AU - Schroeder, DC

AU - Allen, MJ

AU - Holden, MTG

AU - Parkhill, J

AU - Barrell, BG

AU - Churcher, C

AU - Harnlin, N

AU - Mungall, K

AU - Norbertczak, H

AU - Quail, MA

AU - Price, C

AU - Rabbinowitsch, E

AU - Walker, D

AU - Craigon, M

AU - Roy, D

AU - Ghazal, P

PY - 2005/8/12

Y1 - 2005/8/12

N2 - The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

AB - The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

KW - EMILIANIA-HUXLEYI

KW - CELL-DEATH

KW - PHOSPHATE TRANSPORTER

KW - VIRUSES

KW - APOPTOSIS

KW - CERAMIDE

KW - PHYCODNAVIRIDAE

KW - PHYTOPLANKTON

KW - LIMITATION

KW - NITROGEN

U2 - 10.1126/science.1113109

DO - 10.1126/science.1113109

M3 - Article

SN - 0036-8075

VL - 309

SP - 1090

EP - 1092

JO - Science

JF - Science

IS - 5737

ER -

Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

Abstract

UN SDGs

Keywords

Access to Document

Handle.net

Fingerprint

Cite this