Complete genome sequence and lytic phase transcription profile of a Coccolithovirus

WH Wilson*, DC Schroeder, MJ Allen, MTG Holden, J Parkhill, BG Barrell, C Churcher, N Harnlin, K Mungall, H Norbertczak, MA Quail, C Price, E Rabbinowitsch, D Walker, M Craigon, D Roy, P Ghazal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

244 Citations (Scopus)

Abstract

The genus Coccolithovirus is a recently discovered group of viruses that infect the globally important marine calcifying microalga Emiliania huxleyi. Among the 472 predicted genes of the 407,339-base pair genome are a variety of unexpected genes, most notably those involved in biosynthesis of ceramide, a sphingolipid known to induce apoptosis. Uniquely for algal viruses, it also contains six RNA polymerase subunits and a novel promoter, suggesting this virus encodes its own transcription machinery. Microarray transcriptomic analysis reveals that 65% of the predicted virus-encoded genes are expressed during lytic infection of E. huxleyi.

Original languageEnglish
Pages (from-to)1090-1092
Number of pages3
JournalScience
Volume309
Issue number5737
DOIs
Publication statusPublished - 12 Aug 2005

Keywords

  • EMILIANIA-HUXLEYI
  • CELL-DEATH
  • PHOSPHATE TRANSPORTER
  • VIRUSES
  • APOPTOSIS
  • CERAMIDE
  • PHYCODNAVIRIDAE
  • PHYTOPLANKTON
  • LIMITATION
  • NITROGEN

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