Complete genome of acute rheumatic fever-associated serotype M5 Streptococcus pyogenes strain Manfredo

Matthew T. G. Holden*, Annabel Scott, Inna Cherevach, Tracey Chillingworth, Carol Churcher, Ann Cronin, Linda Dowd, Theresa Feltwell, Nancy Hamlin, Simon Holroyd, Kay Jagels, Sharon Moule, Karen Mungall, Michael A. Quail, Claire Price, Ester Rabbinowitsch, Sarah Sharp, Jason Skelton, Sally Whitehead, Bart G. BarrellMichael Kehoe, Julian Parkhill

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)

Abstract

Comparisons of the 1.84-Mb genome of serotype M5 Streptococcus pyogenes strain Manfredo with previously sequenced genomes emphasized the role of prophages in diversification of S. pyogenes and the close relationship between strain Manfredo and MGAS8232, another acute rheumatic fever-associated strain.

Original languageEnglish
Pages (from-to)1473-1477
Number of pages5
JournalJournal of Bacteriology
Volume189
Issue number4
DOIs
Publication statusPublished - Feb 2007

Keywords

  • GROUP-A STREPTOCOCCUS
  • HORIZONTAL GENE-TRANSFER
  • M3 STRAIN
  • SEQUENCE
  • EMERGENCE
  • EVOLUTION
  • CLONE
  • PATHOGENESIS
  • VIRULENCE
  • INSIGHTS

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