Comparison of adrenal and foetal nigral grafts on drug-induced rotation in rats with 6-OHDA lesions

V. J. Brown, S. B. Dunnett*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Separate groups of rats with unilateral 6-OHDA lesions of the nigrostriatal pathway received intrastriatal foetal (E14) substantia nigra suspension grafts, intrastriatal postnatal (P22-25) adrenal medulla suspension grafts using either collagenaseor trypsin-based dissociation procedures, intraventricular adrenal medulla grafts, or remained with lesions alone. Rats with nigral or adrenal suspension grafts, but not rats with adrenal solid grafts, showed reduced apomorphine-induced rotation in comparison with lesion rats. The nigral graft group alone showed substantial reduction of amphetamine-induced rotation, and this was the only group manifesting good long-term graft survival. These results indicate that nigral and adrenal grafts do not have comparable mechanisms of functional action, and suggest that adrenal grafts can ameliorate apomorphine-induced rotation by a non-specific mechanism.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalExperimental Brain Research
Volume78
Issue number1
DOIs
Publication statusPublished - Nov 1989

Keywords

  • Adrenal grafts
  • Nigral grafts
  • Rat
  • Rotation

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