Comparative Analyses of a Family of Potential Self-Replicators: The Subtle Interplay between Molecular structure and the Efficacy of Self-Replication

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Abstract

It is envisioned that protocols based on self-replication will emerge as a formidable synthetic apparatus for the production of nanoscale assemblies through molecular structures that are capable of automultiplication with high reaction rates and selectivities. To achieve this goal, a complete understanding of the relationship between molecular structure and replication efficiency is necessary. Rigorous experimental and theoretical analyses of a series of self-complementary scaffolds that are intimately related in a constitutional sense, manufactured through the Diels-Alder reaction of complementary subunits, were undertaken. Experimental and computational methods were employed to map the key determinants that dictate the emergence of self-replicative function, as well as the efficiency, rate and selectivity of the self-replicative processes.

Original languageEnglish
Pages (from-to)6829-6840
Number of pages12
JournalChemistry - A European Journal
Volume12
Issue number26
DOIs
Publication statusPublished - 6 Sept 2006

Keywords

  • kinetics
  • molecular recognition
  • recognition-mediated reactions
  • self-replication
  • supramolecular chemistry
  • DIELS-ALDER REACTION
  • DIPOLAR CYCLOADDITION REACTION
  • RECOGNITION-INDUCED CONTROL
  • INTRAMOLECULAR REACTIONS
  • ENANTIOMERIC EXCESS
  • HYDROGEN-BOND
  • SOLID-STATE
  • LEWIS ACID
  • ASYMMETRIC AUTOCATALYSIS
  • SUPRAMOLECULAR CHEMISTRY

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