Abstract
It is envisioned that protocols based on self-replication will emerge as a formidable synthetic apparatus for the production of nanoscale assemblies through molecular structures that are capable of automultiplication with high reaction rates and selectivities. To achieve this goal, a complete understanding of the relationship between molecular structure and replication efficiency is necessary. Rigorous experimental and theoretical analyses of a series of self-complementary scaffolds that are intimately related in a constitutional sense, manufactured through the Diels-Alder reaction of complementary subunits, were undertaken. Experimental and computational methods were employed to map the key determinants that dictate the emergence of self-replicative function, as well as the efficiency, rate and selectivity of the self-replicative processes.
Original language | English |
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Pages (from-to) | 6829-6840 |
Number of pages | 12 |
Journal | Chemistry - A European Journal |
Volume | 12 |
Issue number | 26 |
DOIs | |
Publication status | Published - 6 Sept 2006 |
Keywords
- kinetics
- molecular recognition
- recognition-mediated reactions
- self-replication
- supramolecular chemistry
- DIELS-ALDER REACTION
- DIPOLAR CYCLOADDITION REACTION
- RECOGNITION-INDUCED CONTROL
- INTRAMOLECULAR REACTIONS
- ENANTIOMERIC EXCESS
- HYDROGEN-BOND
- SOLID-STATE
- LEWIS ACID
- ASYMMETRIC AUTOCATALYSIS
- SUPRAMOLECULAR CHEMISTRY