Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis

F Vincent, T M Gloster, J Macdonald, C Morland, R V Stick, F M V Dias, J A M Prates, C M G A Fontes, H J Gilbert, G J Davies

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)
Original languageEnglish
Pages (from-to)1596-1599
Number of pages4
JournalChemBioChem
Volume5
Issue number11
DOIs
Publication statusPublished - 5 Nov 2004

Keywords

  • carbohydrates
  • enzyme catalysis
  • glycosides
  • inhibitors
  • lactams
  • GLYCOSYL-ENZYME INTERMEDIATE
  • X-RAY CRYSTALLOGRAPHY
  • GLYCOSIDASE INHIBITORS
  • SUBSTRATE-SPECIFICITY
  • COVALENT-INTERMEDIATE
  • CRYSTAL-STRUCTURE
  • TRANSITION-STATE
  • KINETIC-ANALYSIS
  • MECHANISM
  • DISTORTION

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