Combination of caspofungin or anidulafungin with antimicrobial peptides results in potent synergistic killing of Candida albicans and Candida glabrata in vitro

Mark R. Harris, Peter John Coote

Research output: Contribution to journalArticlepeer-review

34 Citations (Scopus)

Abstract

Administering synergistic combinations of antifungals could be a route to overcome problems with toxicity and the development of resistance. Combination of the echinocandins caspofungin or anidulafungin with a range of structurally diverse antimicrobial peptides resulted in potent synergistic killing of Candida spp. in vitro. Fungicidal synergy was measured by calculating fractional inhibitory concentration indices from checkerboard assays as well as loss of viability. Inhibitory combinations of the antifungals did not induce cytotoxicity in vitro. However, in a murine model of systemic candidiasis, co-administration of caspofungin with one example of the cationic peptides tested, ranalexin, did not show enhanced efficacy compared with the single treatments alone. Further study using alternative peptides will identify whether this combination approach could represent a novel treatment for fungal pathogens. (C) 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

Original languageEnglish
Pages (from-to)347-356
Number of pages10
JournalInternational Journal of Antimicrobial Agents
Volume35
Issue number4
DOIs
Publication statusPublished - Apr 2010

Keywords

  • Echinocandins
  • Antifungals
  • Synergy
  • Combination therapy
  • Candidiasis
  • INVASIVE FUNGAL-INFECTIONS
  • BLOOD-STREAM INFECTIONS
  • AMPHOTERICIN-B
  • ANTIFUNGAL DRUGS
  • CYCLIC-PEPTIDES
  • MICE
  • EPIDEMIOLOGY
  • ASPERGILLUS
  • MICAFUNGIN
  • RESISTANCE

Fingerprint

Dive into the research topics of 'Combination of caspofungin or anidulafungin with antimicrobial peptides results in potent synergistic killing of Candida albicans and Candida glabrata in vitro'. Together they form a unique fingerprint.

Cite this