Colloidal nanomaterials with mechanically interlocked parts

Interfacing mechanically interlocked molecules (MIMs) with nanoparticles (NPs) integrates switchable and dynamic molecular behaviors with unique size-dependent nanomaterials properties. As solution-processable surface-rich platforms, colloidal NPs bridge the gap between the molecular and macroscopic worlds. These nanoscale scaffolds can, therefore, play a critical role in helping to coordinate, correlate, and amplify molecular mechanical changes effected by responsive mechanically interlocked molecular machines to produce useful macroscopic outcomes. Combining elements from these two cutting-edge research fields entails significant synthetic and analytical challenges. This chapter examines the various architectural possibilities whereby mechanically interlocked structures can be interfaced with colloidal NPs. Pioneering studies that established the feasibility of MIM–NP hybrids are described. Subsequently, the application of MIMs to control NP properties, govern the uptake and release of cargos from nanodelivery vehicles, and to construct dynamic NP assemblies is explored. In doing so, the outstanding challenges and considerable potential for innovation in the structure, properties, and functionality of MIM–NP hybrids are highlighted.