Coagulatory defects in type-1 and type-2 diabetes

Amelie Isabelle Sylvie Sobczak; Alan J. Stewart

doi:10.3390/ijms20246345

Coagulatory defects in type-1 and type-2 diabetes

Amelie Isabelle Sylvie Sobczak, Alan J. Stewart

Research output: Contribution to journal › Review article › peer-review

Abstract

Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

Original language	English
Article number	6345
Number of pages	28
Journal	International Journal of Molecular Sciences
Volume	20
Issue number	24
DOIs	https://doi.org/10.3390/ijms20246345
Publication status	Published - 16 Dec 2019

Keywords

Atherosclerosis
Endothelial dysfunction
Magnesium
Metal ions
Microparticles
Platelets
Thrombosis
Zinc

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/ijms20246345Licence: CC BY

Sobczak-2019-Coagulatory-defects-IJMS-20-06345
© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 1.94 MBLicence: CC BY

https://www.mdpi.com/1422-0067/20/24/6345Licence: CC BY

Zinc-dependant heparin neutralisation: Charecterisation of zinc-dependant heparin neutralisation by fibrinogen and histidine-rich glycoprotein.
Stewart, A. J. (PI) & Pitt, S. J. (CoI)
27/10/15 → 26/10/18
Project: Studentship
Role of zinc in controlling histidine: Role of zinc in controlling histidine-rich glycoprotein complex formation: Implications for the development of thrombotic complications.
Stewart, A. J. (PI), Naismith, J. (CoI) & Pitt, S. J. (CoI)
8/06/15 → 7/06/18
Project: Standard

Cite this

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title = "Coagulatory defects in type-1 and type-2 diabetes",

abstract = "Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes. ",

keywords = "Atherosclerosis, Endothelial dysfunction, Magnesium, Metal ions, Microparticles, Platelets, Thrombosis, Zinc",

author = "Sobczak, {Amelie Isabelle Sylvie} and Stewart, {Alan J.}",

note = "This research was funded by British Heart Foundation, grant numbers PG/15/9/31270 and FS/15/42/31556.",

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doi = "10.3390/ijms20246345",

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volume = "20",

journal = "International Journal of Molecular Sciences",

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TY - JOUR

T1 - Coagulatory defects in type-1 and type-2 diabetes

AU - Sobczak, Amelie Isabelle Sylvie

AU - Stewart, Alan J.

N1 - This research was funded by British Heart Foundation, grant numbers PG/15/9/31270 and FS/15/42/31556.

PY - 2019/12/16

Y1 - 2019/12/16

N2 - Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

AB - Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

KW - Atherosclerosis

KW - Endothelial dysfunction

KW - Magnesium

KW - Metal ions

KW - Microparticles

KW - Platelets

KW - Thrombosis

KW - Zinc

U2 - 10.3390/ijms20246345

DO - 10.3390/ijms20246345

M3 - Review article

SN - 1422-0067

VL - 20

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

IS - 24

M1 - 6345

ER -

Coagulatory defects in type-1 and type-2 diabetes

Abstract

Keywords

UN SDGs

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Projects

Zinc-dependant heparin neutralisation: Charecterisation of zinc-dependant heparin neutralisation by fibrinogen and histidine-rich glycoprotein.

Role of zinc in controlling histidine: Role of zinc in controlling histidine-rich glycoprotein complex formation: Implications for the development of thrombotic complications.

Cite this