CLIP-region mediated interaction of Invariant Chain with MHC class I molecules.

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13 Citations (Scopus)

Abstract

An association between the MHC class II chaperone molecule Invariant chain (Ii) and MHC class I molecules is known to occur, but the basis of the interaction is undetermined. Evidence is presented here that the CLIP region of Ii is involved in this interaction. A peptide encoding residues 91-99 of CLIP (MRMATPLLM) stabilised multiple MHC class I alleles, with the methionine residue at position 99 having a crucial role in binding to H2-K-b, whereas methionine at position 91 also appeared important in binding to RT1-A(a). Ii can also be detected in the class I MHC peptide loading complex. These data provide an explanation for the association of Ii and MHC class I molecules. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Original languageEnglish
Pages (from-to)3112-3116
Number of pages5
JournalFEBS Letters
Volume580
DOIs
Publication statusPublished - 29 May 2006

Keywords

  • MHC class I
  • invariant chain
  • antigen presentation
  • peptide loading complex
  • MAJOR HISTOCOMPATIBILITY COMPLEX
  • CROSS-PRESENTATION
  • PEPTIDE-BINDING
  • ASSOCIATION
  • TAPASIN
  • IDENTIFICATION
  • SPECIFICITY
  • SUBUNITS
  • HLA-B27

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