Chemoselective ruthenium-catalysed reduction of carboxylic acids

Jose Antonio Fernandez Salas, Steven Patrick Nolan, Simone Manzini

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

A very general and efficient catalytic protocol
for the selective reduction of carboxylic acids
to their corresponding alcohols under mild conditions
is described. Various carboxylic acids, including
benzoic acids, were reduced in good yields using
the presented methodology. The ruthenium-catalysed
method yields a highly chemoselective reduction
permitting the reduction of a carboxylic acid
functionality in the presence of numerous other potentially
reducible moieties.
Original languageEnglish
Pages (from-to)308-312
Number of pages5
JournalAdvanced Synthesis & Catalysis
Volume356
Issue number2-3
Early online date2 Feb 2014
DOIs
Publication statusPublished - 10 Feb 2014

Keywords

  • Carboxylic acids
  • Homogenous catalysis
  • Hydrosilylation
  • Reduction
  • Ruthenium

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