Chemoselective ruthenium-catalysed reduction of carboxylic acids

Jose Antonio Fernandez Salas; Steven Patrick Nolan; Simone Manzini

doi:10.1002/adsc.201301088

Chemoselective ruthenium-catalysed reduction of carboxylic acids

Jose Antonio Fernandez Salas, Steven Patrick Nolan, Simone Manzini

Research output: Contribution to journal › Article › peer-review

Abstract

A very general and efficient catalytic protocol
for the selective reduction of carboxylic acids
to their corresponding alcohols under mild conditions
is described. Various carboxylic acids, including
benzoic acids, were reduced in good yields using
the presented methodology. The ruthenium-catalysed
method yields a highly chemoselective reduction
permitting the reduction of a carboxylic acid
functionality in the presence of numerous other potentially
reducible moieties.

Original language	English
Pages (from-to)	308-312
Number of pages	5
Journal	Advanced Synthesis & Catalysis
Volume	356
Issue number	2-3
Early online date	2 Feb 2014
DOIs	https://doi.org/10.1002/adsc.201301088
Publication status	Published - 10 Feb 2014

Keywords

Carboxylic acids
Homogenous catalysis
Hydrosilylation
Reduction
Ruthenium

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10.1002/adsc.201301088

FUNCAT: EU FP7 ERC Advanced Grant - FUNCAT - Fundamental Studies in Organometallic Chemistry and Homogeneous Catalysis
Nolan, S. P. (PI)
European Research Council
1/01/09 → 31/12/14
Project: Standard

Cite this

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title = "Chemoselective ruthenium-catalysed reduction of carboxylic acids",

abstract = "A very general and efficient catalytic protocolfor the selective reduction of carboxylic acidsto their corresponding alcohols under mild conditionsis described. Various carboxylic acids, includingbenzoic acids, were reduced in good yields usingthe presented methodology. The ruthenium-catalysedmethod yields a highly chemoselective reductionpermitting the reduction of a carboxylic acidfunctionality in the presence of numerous other potentiallyreducible moieties.",

keywords = "Carboxylic acids , Homogenous catalysis, Hydrosilylation, Reduction, Ruthenium",

author = "{Fernandez Salas}, {Jose Antonio} and Nolan, {Steven Patrick} and Simone Manzini",

note = "This work is partially supported by the EPSRC UK.",

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doi = "10.1002/adsc.201301088",

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T1 - Chemoselective ruthenium-catalysed reduction of carboxylic acids

AU - Fernandez Salas, Jose Antonio

AU - Nolan, Steven Patrick

AU - Manzini, Simone

N1 - This work is partially supported by the EPSRC UK.

PY - 2014/2/10

Y1 - 2014/2/10

N2 - A very general and efficient catalytic protocolfor the selective reduction of carboxylic acidsto their corresponding alcohols under mild conditionsis described. Various carboxylic acids, includingbenzoic acids, were reduced in good yields usingthe presented methodology. The ruthenium-catalysedmethod yields a highly chemoselective reductionpermitting the reduction of a carboxylic acidfunctionality in the presence of numerous other potentiallyreducible moieties.

AB - A very general and efficient catalytic protocolfor the selective reduction of carboxylic acidsto their corresponding alcohols under mild conditionsis described. Various carboxylic acids, includingbenzoic acids, were reduced in good yields usingthe presented methodology. The ruthenium-catalysedmethod yields a highly chemoselective reductionpermitting the reduction of a carboxylic acidfunctionality in the presence of numerous other potentiallyreducible moieties.

KW - Carboxylic acids

KW - Homogenous catalysis

KW - Hydrosilylation

KW - Reduction

KW - Ruthenium

U2 - 10.1002/adsc.201301088

DO - 10.1002/adsc.201301088

M3 - Article

SN - 1615-4150

VL - 356

SP - 308

EP - 312

JO - Advanced Synthesis & Catalysis

JF - Advanced Synthesis & Catalysis

IS - 2-3

ER -

Chemoselective ruthenium-catalysed reduction of carboxylic acids

Abstract

Keywords

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Projects

FUNCAT: EU FP7 ERC Advanced Grant - FUNCAT - Fundamental Studies in Organometallic Chemistry and Homogeneous Catalysis

Cite this