CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .15. DEGRADATION STUDIES OF AZADIRACHTIN LEADING TO C8-C-14 BOND-CLEAVAGE

S V  LEY; P J  LOVELL; A M Z  SLAWIN; S C  SMITH; D J  WILLIAMS; A  WOOD

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .15. DEGRADATION STUDIES OF AZADIRACHTIN LEADING TO C8-C-14 BOND-CLEAVAGE

S V LEY, P J LOVELL, A M Z SLAWIN, S C SMITH, D J WILLIAMS, A WOOD

Research output: Contribution to journal › Article › peer-review

Abstract

The synthesis of a novel macrocyclic carbonate (5) is described which undergoes a base mediated retro-Aldol reaction to cleave the C8-C14 bond giving the highly functionalised decalin unit (7). This key reaction has allowed the preparation of further derivatives for synthetic studies and biological evaluation.

Original language	English
Pages (from-to)	1675-1700
Number of pages	26
Journal	Tetrahedron
Volume	49
Issue number	8
Publication status	Published - 19 Feb 1993

Keywords

ANTIFEEDANT
AZADIRACHTIN
RETRO-ALDOL
KETONES

Cite this

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title = "CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .15. DEGRADATION STUDIES OF AZADIRACHTIN LEADING TO C8-C-14 BOND-CLEAVAGE",

abstract = "The synthesis of a novel macrocyclic carbonate (5) is described which undergoes a base mediated retro-Aldol reaction to cleave the C8-C14 bond giving the highly functionalised decalin unit (7). This key reaction has allowed the preparation of further derivatives for synthetic studies and biological evaluation.",

keywords = "ANTIFEEDANT, AZADIRACHTIN, RETRO-ALDOL, KETONES",

author = "LEY, {S V} and LOVELL, {P J} and SLAWIN, {A M Z} and SMITH, {S C} and WILLIAMS, {D J} and A WOOD",

year = "1993",

month = feb,

day = "19",

language = "English",

volume = "49",

pages = "1675--1700",

journal = "Tetrahedron",

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T1 - CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .15. DEGRADATION STUDIES OF AZADIRACHTIN LEADING TO C8-C-14 BOND-CLEAVAGE

AU - LEY, S V

AU - LOVELL, P J

AU - SLAWIN, A M Z

AU - SMITH, S C

AU - WILLIAMS, D J

AU - WOOD, A

PY - 1993/2/19

Y1 - 1993/2/19

N2 - The synthesis of a novel macrocyclic carbonate (5) is described which undergoes a base mediated retro-Aldol reaction to cleave the C8-C14 bond giving the highly functionalised decalin unit (7). This key reaction has allowed the preparation of further derivatives for synthetic studies and biological evaluation.

AB - The synthesis of a novel macrocyclic carbonate (5) is described which undergoes a base mediated retro-Aldol reaction to cleave the C8-C14 bond giving the highly functionalised decalin unit (7). This key reaction has allowed the preparation of further derivatives for synthetic studies and biological evaluation.

KW - ANTIFEEDANT

KW - AZADIRACHTIN

KW - RETRO-ALDOL

KW - KETONES

M3 - Article

SN - 0040-4020

VL - 49

SP - 1675

EP - 1700

JO - Tetrahedron

JF - Tetrahedron

IS - 8

ER -

CHEMISTRY OF INSECT ANTIFEEDANTS FROM AZADIRACHTA-INDICA .15. DEGRADATION STUDIES OF AZADIRACHTIN LEADING TO C8-C-14 BOND-CLEAVAGE

Abstract

Keywords

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