Abstract
Several echoviruses (EVs) have previously been shown to use decay accelerating factor (DAF) as a cellular receptor. Since DAF is expressed on erythrocytes, EVs that use this receptor cause haemagglutination. Here we show that all EVs that haemagglutinate do so via attachment to DAF and that this interaction can be inhibited by a monoclonal antibody (MAb) specific for DAF domain SCR3. Although the viruses haemagglutinate via DAF some can bind to rhabdomyosarcoma cells from which DAF has been removed and infect in the presence of a MAb against DAF. This suggests that some EVs have the capacity to interact with more than one cellular receptor.
| Original language | English |
|---|---|
| Pages (from-to) | 1707-1713 |
| Number of pages | 7 |
| Journal | Journal of General Virology |
| Volume | 79 |
| Publication status | Published - Jul 1998 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- COMPLEMENT REGULATORY PROTEIN
- MOUTH-DISEASE-VIRUS
- CELLS
- INFECTION
- POLIOVIRUS
- GROWTH
- VLA-2
- B3
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