Changes in plasma free fatty acids associated with type-2 diabetes

Amélie I. S. Sobczak; Claudia A. Blindauer; Alan J. Stewart

doi:10.3390/nu11092022

Changes in plasma free fatty acids associated with type-2 diabetes

Amélie I. S. Sobczak, Claudia A. Blindauer, Alan J. Stewart

Research output: Contribution to journal › Review article › peer-review

Abstract

Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the plasma FFA profile of subjects with T2DM changes is unclear, but it is thought that dietary fats and changes to lipid metabolism are likely to contribute. Therefore, establishing the changes in concentrations of specific FFAs in an individual’s plasma is important. Each type of FFA has different effects on physiological processes, including the regulation of lipolysis and lipogenesis in adipose tissue, inflammation, endocrine signalling and the composition and properties of cellular membranes. Alterations in such processes due to altered plasma FFA concentrations/profiles can potentially result in the development of insulin resistance and coagulatory defects. Finally, fibrates and statins, lipid-regulating drugs prescribed to subjects with T2DM, are also thought to exert part of their beneficial effects by impacting on plasma FFA concentrations. Thus, it is also interesting to consider their effects on the concentration of FFAs in plasma. Collectively, we review how FFAs are altered in T2DM and explore the likely downstream physiological and pathological implications of such changes.

Original language	English
Article number	2022
Number of pages	42
Journal	Nutrients
Volume	11
Issue number	9
DOIs	https://doi.org/10.3390/nu11092022
Publication status	Published - 28 Aug 2019

Keywords

Cardiovascular disease
Fibrates
Free fatty acids
Lipidomics
Metabolism
Statins
Type-2 diabetes mellitus

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/nu11092022Licence: CC BY

Sobczak_2019_Nutrients_Plasmafree_CC
Copyright © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Final published version, 1.17 MBLicence: CC BY

Cite this

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title = "Changes in plasma free fatty acids associated with type-2 diabetes",

abstract = "Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the plasma FFA profile of subjects with T2DM changes is unclear, but it is thought that dietary fats and changes to lipid metabolism are likely to contribute. Therefore, establishing the changes in concentrations of specific FFAs in an individual{\textquoteright}s plasma is important. Each type of FFA has different effects on physiological processes, including the regulation of lipolysis and lipogenesis in adipose tissue, inflammation, endocrine signalling and the composition and properties of cellular membranes. Alterations in such processes due to altered plasma FFA concentrations/profiles can potentially result in the development of insulin resistance and coagulatory defects. Finally, fibrates and statins, lipid-regulating drugs prescribed to subjects with T2DM, are also thought to exert part of their beneficial effects by impacting on plasma FFA concentrations. Thus, it is also interesting to consider their effects on the concentration of FFAs in plasma. Collectively, we review how FFAs are altered in T2DM and explore the likely downstream physiological and pathological implications of such changes.",

keywords = "Cardiovascular disease, Fibrates, Free fatty acids, Lipidomics, Metabolism, Statins, Type-2 diabetes mellitus",

author = "Sobczak, {Am{\'e}lie I. S.} and Blindauer, {Claudia A.} and Stewart, {Alan J.}",

note = "This research was funded by the British Heart Foundation, grant numbers PG/15/9/31270 and FS/15/42/3155 and by the Leverhulme Trust, grant number RPG-2017-214.",

year = "2019",

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doi = "10.3390/nu11092022",

language = "English",

volume = "11",

journal = "Nutrients",

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TY - JOUR

T1 - Changes in plasma free fatty acids associated with type-2 diabetes

AU - Sobczak, Amélie I. S.

AU - Blindauer, Claudia A.

AU - Stewart, Alan J.

N1 - This research was funded by the British Heart Foundation, grant numbers PG/15/9/31270 and FS/15/42/3155 and by the Leverhulme Trust, grant number RPG-2017-214.

PY - 2019/8/28

Y1 - 2019/8/28

N2 - Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the plasma FFA profile of subjects with T2DM changes is unclear, but it is thought that dietary fats and changes to lipid metabolism are likely to contribute. Therefore, establishing the changes in concentrations of specific FFAs in an individual’s plasma is important. Each type of FFA has different effects on physiological processes, including the regulation of lipolysis and lipogenesis in adipose tissue, inflammation, endocrine signalling and the composition and properties of cellular membranes. Alterations in such processes due to altered plasma FFA concentrations/profiles can potentially result in the development of insulin resistance and coagulatory defects. Finally, fibrates and statins, lipid-regulating drugs prescribed to subjects with T2DM, are also thought to exert part of their beneficial effects by impacting on plasma FFA concentrations. Thus, it is also interesting to consider their effects on the concentration of FFAs in plasma. Collectively, we review how FFAs are altered in T2DM and explore the likely downstream physiological and pathological implications of such changes.

AB - Type 2 diabetes mellitus (T2DM) is associated with increased total plasma free fatty acid (FFA) concentrations and an elevated risk of cardiovascular disease. The exact mechanisms by which the plasma FFA profile of subjects with T2DM changes is unclear, but it is thought that dietary fats and changes to lipid metabolism are likely to contribute. Therefore, establishing the changes in concentrations of specific FFAs in an individual’s plasma is important. Each type of FFA has different effects on physiological processes, including the regulation of lipolysis and lipogenesis in adipose tissue, inflammation, endocrine signalling and the composition and properties of cellular membranes. Alterations in such processes due to altered plasma FFA concentrations/profiles can potentially result in the development of insulin resistance and coagulatory defects. Finally, fibrates and statins, lipid-regulating drugs prescribed to subjects with T2DM, are also thought to exert part of their beneficial effects by impacting on plasma FFA concentrations. Thus, it is also interesting to consider their effects on the concentration of FFAs in plasma. Collectively, we review how FFAs are altered in T2DM and explore the likely downstream physiological and pathological implications of such changes.

KW - Cardiovascular disease

KW - Fibrates

KW - Free fatty acids

KW - Lipidomics

KW - Metabolism

KW - Statins

KW - Type-2 diabetes mellitus

UR - https://www.mdpi.com/2072-6643/11/9/2022

U2 - 10.3390/nu11092022

DO - 10.3390/nu11092022

M3 - Review article

SN - 2072-6643

VL - 11

JO - Nutrients

JF - Nutrients

IS - 9

M1 - 2022

ER -

Changes in plasma free fatty acids associated with type-2 diabetes

Abstract

Keywords

UN SDGs

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Cite this

Changes in plasma free fatty acids associated with type-2 diabetes

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

A Quantitive framework linking: A Quantitive framework linking extracellular zinc speciation and cell uptake

Zinc-dependant heparin neutralisation: Charecterisation of zinc-dependant heparin neutralisation by fibrinogen and histidine-rich glycoprotein.

Role of zinc in controlling histidine: Role of zinc in controlling histidine-rich glycoprotein complex formation: Implications for the development of thrombotic complications.

Cite this