Challenges in predicting the change in the cumulative exposure of new tobacco and related products based on emissions and toxicity dose–response data

Yvonne C. M. Staal*, Wieneke Bil, Bas G. H. Bokkers, Lya G. Soeteman-Hernández, W. Edryd Stephens, Reinskje Talhout

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Many novel tobacco products have been developed in recent years. Although many may emit lower levels of several toxicants, their risk in the long term remains unclear. We previously published a method for the exposure assessment of mixtures that can be used to compare the changes in cumulative exposure to carcinogens among tobacco products. While further developing this method by including more carcinogens or to explore its application to non-cancer endpoints, we encountered a lack of data that are required for better-substantiated conclusions regarding differences in exposure between products. In this special communication, we argue the case for more data on adverse health effects, as well as more data on the composition of the emissions from tobacco products. Such information can be used to identify significant changes in relevance to health using the cumulative exposure method with different products and to substantiate regulatory decisions.
Original languageEnglish
Article number10528
Number of pages15
JournalInternational Journal of Environmental Research and Public Health
Volume19
Issue number17
DOIs
Publication statusPublished - 24 Aug 2022

Keywords

  • Tobacco products
  • Carcinogenicity
  • Cardiovascular diseases
  • Heated tobacco
  • Cumulative exposure
  • Relative potency

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