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Abstract
Biological cell lasers are promising novel building blocks of future biocompatible optical systems and offer new approaches to cellular sensing and cytometry in a microfluidic setting. Here, we demonstrate a simple method for providing optical gain by using a variety of standard fluorescent dyes. The dye gain medium can be located inside or outside a cell, or in both, which gives flexibility in experimental design and makes the method applicable to all cell types. Due to the higher refractive index of the cytoplasm compared to the surrounding medium, a cell acts as a convex lens in a planar Fabry-Perot cavity. Its effect on the stability of the laser cavity is analyzed and utilized to suppress lasing outside cells. The resonance modes depend on the shape and internal structure of the cell. As proof of concept, we show how the laser output modes are affected by the osmotic pressure.
Original language | English |
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Pages (from-to) | 27865-27879 |
Number of pages | 14 |
Journal | Optics Express |
Volume | 23 |
Issue number | 21 |
Early online date | 14 Oct 2015 |
DOIs | |
Publication status | Published - 14 Oct 2015 |
Keywords
- Dye lasers
- Cell analysis
- Biological sensing and sensors
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Dive into the research topics of 'Cellular dye lasers: lasing thresholds and sensing in a planar resonator'. Together they form a unique fingerprint.Projects
- 1 Finished
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H2020 ERC Starting Grant ABLASE: H2020 ERC Starting Grant ABLASE (Grant Agreement No. 640012)
Gather, M. C. (PI)
1/06/15 → 31/05/21
Project: Standard