Cell receptors for picornaviruses as determinants of cell tropism and pathogenesis

DJ Evans*, JW Almond

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

80 Citations (Scopus)

Abstract

Recent studies have identified at least nine distinct receptors used by the picornaviruses for cell entry. Does the evolution of receptor usage correlate with the different tropisms observed in this group of viruses, and does this influence pathogenesis, or is it the consequence of another selection mechanism that favours virus survival?.

Original languageEnglish
Pages (from-to)198-202
Number of pages5
JournalTrends in Microbiology
Volume6
Issue number5
Publication statusPublished - May 1998

Keywords

  • DECAY-ACCELERATING FACTOR
  • HUMAN POLIOVIRUS RECEPTOR
  • FACTOR CD55
  • ENCEPHALOMYOCARDITIS VIRUS
  • HUMAN RHINOVIRUS
  • TRANSGENIC MICE
  • VITRONECTIN RECEPTOR
  • COXSACKIEVIRUS A9
  • NASAL SECRETIONS
  • HEPARAN-SULFATE

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