Cell perforation mediated by plasmonic bubbles generated by a single near infrared femtosecond laser pulse

C. Boutopoulos, E. Bergeron, M. Meunier

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We report on transient membrane perforation of living cancer cells using plasmonic gold nanoparticles (AuNPs) enhanced single near infrared (NIR) femtosecond (fs) laser pulse. Under optimized laser energy fluence, single pulse treatment (τ = 45 fs, λ = 800 nm) resulted in 77% cell perforation efficiency and 90% cell viability. Using dark field and ultrafast imaging, we demonstrated that the generation of submicron bubbles around the AuNPs is the necessary condition for the cell membrane perforation. AuNP clustering increased drastically the bubble generation efficiency, thus enabling an effective laser treatment using low energy dose in the NIR optical therapeutical window.
Original languageEnglish
JournalJournal of Biophotonics
Early online date21 Jul 2015
DOIs
Publication statusPublished - 2015

Keywords

  • Nanobubble
  • Gold nanoparticle
  • Ultrafast laser
  • Cell manipulation
  • Nanosurgery

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