Causes of community-acquired bacteremia and patterns of antimicrobial resistance in Vientiane, Laos

Rattanaphone Phetsouvanh, Simmaly Phongmany, Douangdao Soukaloun, Bouachanh Rasachak, Vimone Soukhaseum, Seun Soukhaseum, Kamthavi Frichithavong, Sengmanivong Khounnorath, Bounthom Pengdee, Khamphong Phiasakha, Vang Chu, Khonesavanh Luangxay, Sayadeth Rattanavong, Konkam Sisouk, Valy Keolouangkot, Mayfong Mayxay, Andrew Ramsay, Stuart D Blacksell, Jim Campbell, Bertrand Martinez-AusselMayboun Heuanvongsy, Bounthapaany Bounxouei, Chanpheng Thammavong, Bounkong Syhavong, Michel Strobel, Sharon J Peacock, Nicholas J White, Paul N Newton

Research output: Contribution to journalArticlepeer-review

89 Citations (Scopus)

Abstract

There is no published information on the causes of bacteremia in the Lao PDR (Laos). Between 2000 and 2004, 4512 blood culture pairs were taken from patients admitted to Mahosot Hospital, Vientiane, Laos, with suspected community-acquired bacteremia; 483 (10.7%) cultures grew a clinically significant community-acquired organism, most commonly Salmonella enterica serovar typhi (50.9%), Staphylococcus aureus (19.0%), and Escherichia coli (12.4%). S. aureus bacteremia was common among infants (69.2%), while children 1-5 years had a high frequency of typhoid (44%). Multi-drug-resistant S. Typhi was rare (6%). On multiple logistic regression analysis, typhoid was associated with younger age, longer illness, diarrhea, higher admission temperature, and lower peripheral white blood cell count than non-typhoidal bacteremia. Empirical parenteral ampicillin and gentamicin would have some activity against approximately 88% of clinically significant isolates at a cost of US $1.4/day, an important exception being B. pseudomallei. Bacteremic infants in this setting require an anti-staphylococcal antibiotic.

Original languageEnglish
Pages (from-to)978-85
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume75
Issue number5
Publication statusPublished - Nov 2006

Keywords

  • Anti-Bacterial Agents/pharmacology
  • Bacteremia/diagnosis
  • Blood/microbiology
  • Child, Preschool
  • Community-Acquired Infections/diagnosis
  • Drug Resistance, Bacterial
  • Gram-Negative Bacteria/drug effects
  • Gram-Positive Bacteria/drug effects
  • Humans
  • Laos/epidemiology

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