Catalytic asymmetric alpha-amination of carboxylic acids using isothioureas

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

HBTM-2.1 promotes the direct asymmetric alpha-amination of carboxylic acids with N-aryl-N-aroyldiazenes at low catalyst loadings (as low as 0.25 mol%), giving either 1,3,4-oxadiazin-6-ones or N-protected alpha-amino acid derivatives (upon ring opening) with exquisite enantiocontrol (typically >= 99% ee).

Original languageEnglish
Pages (from-to)2088-2093
Number of pages6
JournalChemical Science
Volume3
Issue number6
DOIs
Publication statusPublished - 2012

Fingerprint

Dive into the research topics of 'Catalytic asymmetric alpha-amination of carboxylic acids using isothioureas'. Together they form a unique fingerprint.

Cite this