Abstract
HBTM-2.1 promotes the direct asymmetric alpha-amination of carboxylic acids with N-aryl-N-aroyldiazenes at low catalyst loadings (as low as 0.25 mol%), giving either 1,3,4-oxadiazin-6-ones or N-protected alpha-amino acid derivatives (upon ring opening) with exquisite enantiocontrol (typically >= 99% ee).
Original language | English |
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Pages (from-to) | 2088-2093 |
Number of pages | 6 |
Journal | Chemical Science |
Volume | 3 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2012 |