Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

Francesca Cardona; Andrea Goti; Camilla Parmeggiani; Paolo Parenti; Matilde Forcella; Paola Fusi; Laura Cipolla; Shirley M. Roberts; Gideon J. Davies; Tracey M. Gloster

doi:10.1039/b926600c

Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

Francesca Cardona, Andrea Goti, Camilla Parmeggiani, Paolo Parenti, Matilde Forcella, Paola Fusi, Laura Cipolla, Shirley M. Roberts, Gideon J. Davies, Tracey M. Gloster

Research output: Contribution to journal › Article › peer-review

41 Citations (Scopus)

Abstract

Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.

Original language	English
Pages (from-to)	2629-2631
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	15
DOIs	https://doi.org/10.1039/b926600c
Publication status	Published - 2010

Keywords

PANCREATIC ALPHA-AMYLASE
ALKALOIDS
CYCLOADDITION
SPECIFICITY
EXPRESSION
SUBSTRATE
MECHANISM
NITRONE

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10.1039/b926600c

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title = "Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases",

abstract = "Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.",

keywords = "PANCREATIC ALPHA-AMYLASE, ALKALOIDS, CYCLOADDITION, SPECIFICITY, EXPRESSION, SUBSTRATE, MECHANISM, NITRONE",

author = "Francesca Cardona and Andrea Goti and Camilla Parmeggiani and Paolo Parenti and Matilde Forcella and Paola Fusi and Laura Cipolla and Roberts, {Shirley M.} and Davies, {Gideon J.} and Gloster, {Tracey M.}",

year = "2010",

doi = "10.1039/b926600c",

language = "English",

volume = "46",

pages = "2629--2631",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "15",

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TY - JOUR

T1 - Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

AU - Cardona, Francesca

AU - Goti, Andrea

AU - Parmeggiani, Camilla

AU - Parenti, Paolo

AU - Forcella, Matilde

AU - Fusi, Paola

AU - Cipolla, Laura

AU - Roberts, Shirley M.

AU - Davies, Gideon J.

AU - Gloster, Tracey M.

PY - 2010

Y1 - 2010

N2 - Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.

AB - Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.

KW - PANCREATIC ALPHA-AMYLASE

KW - ALKALOIDS

KW - CYCLOADDITION

KW - SPECIFICITY

KW - EXPRESSION

KW - SUBSTRATE

KW - MECHANISM

KW - NITRONE

U2 - 10.1039/b926600c

DO - 10.1039/b926600c

M3 - Article

SN - 1359-7345

VL - 46

SP - 2629

EP - 2631

JO - Chemical Communications

JF - Chemical Communications

IS - 15

ER -

Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

Abstract

Keywords

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