Casuarine-6-O-alpha-D-glucoside and its analogues are tight binding inhibitors of insect and bacterial trehalases

Francesca Cardona, Andrea Goti, Camilla Parmeggiani, Paolo Parenti, Matilde Forcella, Paola Fusi, Laura Cipolla, Shirley M. Roberts, Gideon J. Davies, Tracey M. Gloster

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Two novel casuarine-6-alpha-D-glucoside analogues, as well as the parent compound, were synthesized and tested as inhibitors towards Chironomus riparius, mammalian pig kidney and Escherichia coli trehalases. Their potent and selective activity is promising for the development of new insecticides.

Original languageEnglish
Pages (from-to)2629-2631
Number of pages3
JournalChemical Communications
Volume46
Issue number15
DOIs
Publication statusPublished - 2010

Keywords

  • PANCREATIC ALPHA-AMYLASE
  • ALKALOIDS
  • CYCLOADDITION
  • SPECIFICITY
  • EXPRESSION
  • SUBSTRATE
  • MECHANISM
  • NITRONE

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