TY - JOUR
T1 - Case-Control Genome-Wide Association Study of Attention-Deficit/Hyperactivity Disorder
AU - Neale, Benjamin M.
AU - Medland, Sarah
AU - Ripke, Stephan
AU - Anney, Richard J. L.
AU - Asherson, Philip
AU - Buitelaar, Jan
AU - Franke, Barbara
AU - Gill, Michael
AU - Kent, Lindsey
AU - Holmans, Peter
AU - Middleton, Frank
AU - Thapar, Anita
AU - Lesch, Klaus-Peter
AU - Faraone, Stephen V.
AU - Daly, Mark
AU - Nguyen, Thuy Trang
AU - Schaefer, Helmut
AU - Steinhausen, Hans-Christoph
AU - Reif, Andreas
AU - Renner, Tobias J.
AU - Romanos, Marcel
AU - Romanos, Jasmin
AU - Warnke, Andreas
AU - Walitza, Susanne
AU - Freitag, Christine
AU - Meyer, Jobst
AU - Palmason, Haukur
AU - Rothenberger, Aribert
AU - Hawi, Ziarih
AU - Sergeant, Joseph
AU - Roeyers, Herbert
AU - Mick, Eric
AU - Biederman, Joseph
AU - IMAGE II Consortium
PY - 2010/9
Y1 - 2010/9
N2 - Objective: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed. Method: We used case-control analyses of 896 cases with DSM-IV ADHD genotvped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model. Results: No genomewide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1. Conclusions: The current analyses are a useful addition to the present literature and will make a valuable contribution to future meta-analyses. The candidate gene findings are consistent with a prior meta-analysis in suggesting that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(9):906-920.
AB - Objective: Although twin and family studies have shown attention-deficit/hyperactivity disorder (ADHD) to be highly heritable, genetic variants influencing the trait at a genome-wide significant level have yet to be identified. Thus additional genomewide association studies (GWAS) are needed. Method: We used case-control analyses of 896 cases with DSM-IV ADHD genotvped using the Affymetrix 5.0 array and 2,455 repository controls screened for psychotic and bipolar symptoms genotyped using Affymetrix 6.0 arrays. A consensus SNP set was imputed using BEAGLE 3.0, resulting in an analysis dataset of 1,033,244 SNPs. Data were analyzed using a generalized linear model. Results: No genomewide significant associations were found. The most significant results implicated the following genes: PRKG1, FLNC, TCERG1L, PPM1H, NXPH1, PPM1H, CDH13, HK1, and HKDC1. Conclusions: The current analyses are a useful addition to the present literature and will make a valuable contribution to future meta-analyses. The candidate gene findings are consistent with a prior meta-analysis in suggesting that the effects of ADHD risk variants must, individually, be very small and/or include multiple rare alleles. J. Am. Acad. Child Adolesc. Psychiatry, 2010;49(9):906-920.
KW - ADHD
KW - genetics
KW - genome-wide association
KW - imputation
KW - DEFICIT HYPERACTIVITY DISORDER
KW - PROTEIN-KINASE-I
KW - INTERNATIONAL HAPMAP PROJECT
KW - SUBSTANCE USE DISORDERS
KW - LONG-TERM POTENTIATION
KW - MOLECULAR-GENETICS
KW - SUSCEPTIBILITY LOCI
KW - BIPOLAR DISORDER
KW - COMMON VARIANTS
KW - CANDIDATE GENES
UR - http://www.scopus.com/inward/record.url?scp=77956180603&partnerID=8YFLogxK
U2 - 10.1016/j.jaac.2010.06.007
DO - 10.1016/j.jaac.2010.06.007
M3 - Article
SN - 0890-8567
VL - 49
SP - 906
EP - 920
JO - Journal of the American Academy of Child and Adolescent Psychiatry
JF - Journal of the American Academy of Child and Adolescent Psychiatry
IS - 9
ER -