Cadmium(II) Schiff base complex containing 5-fluoroisatin moiety: synthesis, characterization, antibacterial activity and structural studies

Mohd Abdul Fatah Abdul Manan*, David B. Cordes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

The Schiff base ligand, HSB5FISA (H1), obtained by the condensation of S-benzyldithiocarbazate with 5-fluoroisatin, has been employed to synthesize a new cadmium(II) complex, Cd(SB5FISA)2 (2) (SB5FISA = monoanionic form of H1). The complex has been characterized by elemental analysis, molar conductivity, magnetic susceptibility, inductively coupled plasma atomic emission spectroscopy (ICP-AES), Fourier-transform infrared spectroscopy (FT-IR) and ultraviolet-visible spectroscopy (UV-Vis). The crystallographic study of Cd(SB5FISA)2•2DMSO (2a) (DMSO = dimethyl sulfoxide) was conducted using single-crystal X-ray diffraction. The crystal structure of 2a confirmed the presence of six-coordinated cadmium in a distorted octahedral environment. Ligand H1 behaves in a tridentate monoanionic fashion, coordinating to a cadmium(II) metal centre through the thiolate sulfur, azomethine nitrogen and carbonyl oxygen. The antibacterial activity of both H1 and 2 was examined against four different bacterial strains using the disc diffusion method. Complex 2 showed significant inhibitory effect against Bacillus subtilis with an inhibition zone of 14 mm, comparable to the standard antibiotic streptomycin.
Original languageEnglish
Article number5796
Number of pages8
JournalTrends in Sciences
Volume19
Issue number18
Early online date28 Aug 2022
DOIs
Publication statusPublished - 15 Sept 2022

Keywords

  • Cadmium(II)
  • Dithiocarbazate
  • 5-fluoroisatin
  • Single-crystal structure
  • Antibacterial

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