Brain swelling and death in children with cerebral malaria

Karl B Seydel, Samuel D Kampondeni, Clarissa Valim, Michael J Potchen, Danny A Milner, Francis W Muwalo, Gretchen L Birbeck, William G Bradley, Lindsay L Fox, Simon J Glover, Colleen A Hammond, Robert S Heyderman, Cowles A Chilingulo, Malcolm E Molyneux, Terrie E Taylor

Research output: Contribution to journalArticlepeer-review

273 Citations (Scopus)


Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.
Original languageEnglish
Pages (from-to)1126-37
Number of pages12
JournalNew England Journal of Medicine
Issue number12
Publication statusPublished - 19 Mar 2015


  • Brain
  • Brain Edema
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Infant
  • Magnetic Resonance Imaging
  • Malaria
  • Malawi
  • Male
  • Organ Size
  • Papilledema
  • Cerebral


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