Brain swelling and death in children with cerebral malaria

Karl B Seydel; Samuel D Kampondeni; Clarissa Valim; Michael J Potchen; Danny A Milner; Francis W Muwalo; Gretchen L Birbeck; William G Bradley; Lindsay L Fox; Simon J Glover; Colleen A Hammond; Robert S Heyderman; Cowles A Chilingulo; Malcolm E Molyneux; Terrie E Taylor

doi:10.1056/NEJMoa1400116

Brain swelling and death in children with cerebral malaria

Karl B Seydel, Samuel D Kampondeni, Clarissa Valim, Michael J Potchen, Danny A Milner, Francis W Muwalo, Gretchen L Birbeck, William G Bradley, Lindsay L Fox, Simon J Glover, Colleen A Hammond, Robert S Heyderman, Cowles A Chilingulo, Malcolm E Molyneux, Terrie E Taylor

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.

Original language	English
Pages (from-to)	1126-37
Number of pages	12
Journal	New England Journal of Medicine
Volume	372
Issue number	12
DOIs	https://doi.org/10.1056/NEJMoa1400116
Publication status	Published - 19 Mar 2015

Keywords

Brain
Brain Edema
Child
Child, Preschool
Female
Humans
Infant
Magnetic Resonance Imaging
Malaria
Malawi
Male
Organ Size
Papilledema
Cerebral

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1056/NEJMoa1400116

Glover_BrainSwelling_NEJoM_FinalPubVersion
© 2015 Massachusetts Medical Society. All rights reserved. This work is made available online in accordance with the publisher’s policies. This is the final published version of the work, which was originally published at https://dx.doi.org/10.1056/NEJMoa1400116
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Seydel, K. B., Kampondeni, S. D., Valim, C., Potchen, M. J., Milner, D. A., Muwalo, F. W., Birbeck, G. L., Bradley, W. G., Fox, L. L., Glover, S. J., Hammond, C. A., Heyderman, R. S., Chilingulo, C. A., Molyneux, M. E., & Taylor, T. E. (2015). Brain swelling and death in children with cerebral malaria. New England Journal of Medicine, 372(12), 1126-37. https://doi.org/10.1056/NEJMoa1400116

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title = "Brain swelling and death in children with cerebral malaria",

abstract = "Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.",

keywords = "Brain, Brain Edema, Child, Child, Preschool, Female, Humans, Infant, Magnetic Resonance Imaging, Malaria, Malawi, Male, Organ Size, Papilledema, Cerebral",

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note = "Supported by a grant (5R01AI034969) from the National Institutes of Health and by a Strategic Award for the Malawi–Liverpool–Wellcome Clinical Research Programme from the Wellcome Trust U.K. General Electric Healthcare donated the Signa 0.35-T magnetic resonance imager (MRI) used in this work, and the Michigan State University College of Osteopathic Medicine sponsored the construction of the building that houses the MRI in Malawi.",

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AU - Seydel, Karl B

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AU - Milner, Danny A

AU - Muwalo, Francis W

AU - Birbeck, Gretchen L

AU - Bradley, William G

AU - Fox, Lindsay L

AU - Glover, Simon J

AU - Hammond, Colleen A

AU - Heyderman, Robert S

AU - Chilingulo, Cowles A

AU - Molyneux, Malcolm E

AU - Taylor, Terrie E

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PY - 2015/3/19

Y1 - 2015/3/19

N2 - Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.

AB - Case fatality rates among African children with cerebral malaria remain in the range of 15 to 25%. The key pathogenetic processes and causes of death are unknown, but a combination of clinical observations and pathological findings suggests that increased brain volume leading to raised intracranial pressure may play a role. Magnetic resonance imaging (MRI) became available in Malawi in 2009, and we used it to investigate the role of brain swelling in the pathogenesis of fatal cerebral malaria in African children.

KW - Brain

KW - Brain Edema

KW - Child

KW - Child, Preschool

KW - Female

KW - Humans

KW - Infant

KW - Magnetic Resonance Imaging

KW - Malaria

KW - Malawi

KW - Male

KW - Organ Size

KW - Papilledema

KW - Cerebral

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DO - 10.1056/NEJMoa1400116

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VL - 372

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EP - 1137

JO - New England Journal of Medicine

JF - New England Journal of Medicine

IS - 12

ER -

Brain swelling and death in children with cerebral malaria

Abstract

Keywords

UN SDGs

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