Brain MRI of children with retinopathy-negative cerebral malaria

D.G. Postels, C. Li, G.L. Birbeck, T.E. Taylor, K.B. Seydel, S.D. Kampondeni, S.J. Glover, M.J. Potchen

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9 Citations (Scopus)

Abstract

Our goals were to understand the brain magnetic resonance imaging (MRI) findings in children with retinopathy-negative cerebral malaria (CM) and investigate whether any findings on acute MRI were associated with adverse outcomes. We performed MRI scans on children admitted to the hospital in Blantyre, Malawi with clinically defined CM. Two hundred and seventeen children were imaged during the study period; 44 patients were malarial retinopathy-negative; and 173 patients were retinopathy-positive. We compared MRI findings in children with retinopathy-negative and retinopathy-positive CM. In children who were retinopathy-negative, we identified MRI variables that were associated with death and adverse neurologic outcomes. On multivariate analysis, cortical diffusion weighted imaging (DWI) abnormality and increased brain volume were strongly associated with neurologic morbidity in survivors. Investigations to explore the underlying pathophysiologic processes responsible for these MRI changes are warranted.
Original languageEnglish
Pages (from-to)943-949
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume91
Issue number5
DOIs
Publication statusPublished - 1 Nov 2014

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