Blue-light phase shifts PER3 gene expression in human leukocytes

Katrin Ackermann, Tracey L Sletten, Victoria L Revell, Simon N Archer, Debra J Skene

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

The timing of clock gene expression in human leukocytes was investigated following a phase-advancing light stimulus to determine whether the response is wavelength- and/or age-dependent. PERIOD3 (PER3) clock gene expression in leukocytes and plasma melatonin were analyzed before and after monochromatic blue and green light exposure. Significant phase advances were observed in the peak timing of both PER3 expression and melatonin following blue but not green light. The amplitude of the PER3 rhythm at baseline was significantly reduced with age. However, age did not affect the response of the PER3 rhythm to light.

Original languageEnglish
Pages (from-to)769-79
Number of pages11
JournalChronobiology International
Volume26
Issue number4
DOIs
Publication statusPublished - May 2009

Keywords

  • Adult
  • Age Factors
  • Aged
  • Gene Expression Regulation
  • Humans
  • Kinetics
  • Leukocytes
  • Light
  • Male
  • Melatonin
  • Middle Aged
  • Nuclear Proteins
  • Period Circadian Proteins
  • Transcription Factors
  • Young Adult
  • Journal Article
  • Research Support, Non-U.S. Gov't

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