Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

Anna Chiara De Luca; Peter Reader-Harris; Michael Mazilu; Stefano Manago; Stefania Mariggio; Daniela Corda; Andrea Di Falco

doi:10.1117/12.2039697

Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

Anna Chiara De Luca^*, Peter Reader-Harris, Michael Mazilu, Stefano Manago, Stefania Mariggio, Daniela Corda, Andrea Di Falco

^*Corresponding author for this work

School of Physics and Astronomy

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.

Original language	English
Title of host publication	PLASMONICS IN BIOLOGY AND MEDICINE XI
Editors	T VoDinh, Lakowicz
Publisher	SPIE
Number of pages	7
DOIs	https://doi.org/10.1117/12.2039697
Publication status	Published - 2014
Event	Conference on Plasmonics in Biology and Medicine XI - San Francisco, Canada Duration: 1 Feb 2014 → 2 Feb 2014

Publication series

Name	Proceedings of SPIE
Publisher	SPIE-INT SOC OPTICAL ENGINEERING
Volume	8957
ISSN (Print)	0277-786X

Conference

Conference	Conference on Plasmonics in Biology and Medicine XI
Country/Territory	Canada
Period	1/02/14 → 2/02/14

Keywords

SERS
Cancer diagnostic
Glycerophosphoinositol
Biosensor
Reproducibility
SURFACE-ENHANCED RAMAN
SPECTROSCOPY
SCATTERING
SILVER

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1117/12.2039697

METAFLEX-Metamaterials on Flexible: METAFLEX-Metamaterials on Flexible optically transparent substrate
Di Falco, A. (PI)
EPSRC
1/08/10 → 31/07/15
Project: Fellowship

Cite this

@inproceedings{b16846b9dcc045d5adad975d0ced6e59,

title = "Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates",

abstract = "We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.",

keywords = "SERS, Cancer diagnostic, Glycerophosphoinositol, Biosensor, Reproducibility, SURFACE-ENHANCED RAMAN, SPECTROSCOPY, SCATTERING, SILVER",

author = "{De Luca}, {Anna Chiara} and Peter Reader-Harris and Michael Mazilu and Stefano Manago and Stefania Mariggio and Daniela Corda and {Di Falco}, Andrea",

year = "2014",

doi = "10.1117/12.2039697",

language = "English",

series = "Proceedings of SPIE",

publisher = "SPIE",

editor = "T VoDinh and Lakowicz",

booktitle = "PLASMONICS IN BIOLOGY AND MEDICINE XI",

address = "United States",

note = "Conference on Plasmonics in Biology and Medicine XI ; Conference date: 01-02-2014 Through 02-02-2014",

}

De Luca, AC, Reader-Harris, P, Mazilu, M, Manago, S, Mariggio, S, Corda, D & Di Falco, A 2014, Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates. in T VoDinh & Lakowicz (eds), PLASMONICS IN BIOLOGY AND MEDICINE XI. Proceedings of SPIE, vol. 8957, SPIE, Conference on Plasmonics in Biology and Medicine XI, Canada, 1/02/14. https://doi.org/10.1117/12.2039697

TY - GEN

T1 - Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

AU - De Luca, Anna Chiara

AU - Reader-Harris, Peter

AU - Mazilu, Michael

AU - Manago, Stefano

AU - Mariggio, Stefania

AU - Corda, Daniela

AU - Di Falco, Andrea

PY - 2014

Y1 - 2014

N2 - We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.

AB - We developed a SERS biosensor based on gold fishnets fabricated by using e-beam lithography. This device is used for glycerophosphoinositol (GroPIns) molecule sensing. GroPIns is an abundant component of cell cytosol and high GroPIns levels have been reported in several tumour cells. We demonstrate that our SERS sensor is able to accurately and quantitatively determine the concentration of GroPIns. These results indicate that SERS may provide a novel platform technology to identify GroPIns profiles in disease pathogenesis.

KW - SERS

KW - Cancer diagnostic

KW - Glycerophosphoinositol

KW - Biosensor

KW - Reproducibility

KW - SURFACE-ENHANCED RAMAN

KW - SPECTROSCOPY

KW - SCATTERING

KW - SILVER

U2 - 10.1117/12.2039697

DO - 10.1117/12.2039697

M3 - Conference contribution

T3 - Proceedings of SPIE

BT - PLASMONICS IN BIOLOGY AND MEDICINE XI

A2 - VoDinh, T

A2 - Lakowicz, null

PB - SPIE

T2 - Conference on Plasmonics in Biology and Medicine XI

Y2 - 1 February 2014 through 2 February 2014

ER -

Biomolecular sensing for cancer diagnostics using highly reproducible SERS substrates

Abstract

Publication series

Conference

Keywords

UN SDGs

Access to Document

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Projects

METAFLEX-Metamaterials on Flexible: METAFLEX-Metamaterials on Flexible optically transparent substrate

Cite this