Bioinspired Catalyst Design and Artificial Metalloenzymes

Peter J. Deuss, Rene den Heeten, Wouter Laan*, Paul C. J. Kamer

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Many bioinspired transition-metal catalysts have been developed over the recent years. In this review the progress in the design and application of ligand systems based on peptides and DNA and the development of artificial metalloenzymes are reviewed with a particular emphasis on the combination of phosphane ligands with powerful molecular recognition and shape selectivity of biomolecules. The various approaches for the assembly of these catalytic systems will be highlighted, and the possibilities that the use of the building blocks of Nature provide for catalyst optimisation strategies are discussed.

Original languageEnglish
Pages (from-to)4680-4698
Number of pages19
JournalChemistry - A European Journal
Volume17
Issue number17
DOIs
Publication statusPublished - Apr 2011

Keywords

  • CHIRAL PHOSPHINE-LIGANDS
  • artificial metalloenzymes
  • TRANSITION-METAL COMPLEXES
  • COMPUTATIONAL ENZYME DESIGN
  • phosphane ligands
  • DNAzymes
  • HUMAN SERUM-ALBUMIN
  • SUBSTITUTED CARBONIC-ANHYDRASE
  • ASYMMETRIC ALLYLIC ALKYLATION
  • CONTAINING AMINO-ACIDS
  • homogeneous catalysis
  • ligand design
  • BIOTIN-AVIDIN TECHNOLOGY
  • DIELS-ALDER REACTION
  • SOLID-PHASE SYNTHESIS

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