Bioabsorbable polymer optical waveguides for deep-tissue photomedicine

Sedat Nizamoglu; Malte Christian Gather; Matjaž Humar; Myunghwan Choi; Seonghoon Kim; Ki Su Kim; Sei Kwang Hahn; Giuliano Scarcelli; Mark Randolph; Robert W. Redmond; Seok Hyun Yun

doi:10.1038/ncomms10374

Bioabsorbable polymer optical waveguides for deep-tissue photomedicine

Sedat Nizamoglu, Malte Christian Gather, Matjaž Humar, Myunghwan Choi, Seonghoon Kim, Ki Su Kim, Sei Kwang Hahn, Giuliano Scarcelli, Mark Randolph, Robert W. Redmond, Seok Hyun Yun

Research output: Contribution to journal › Article › peer-review

Abstract

Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.

Original language	English
Article number	10374
Number of pages	7
Journal	Nature Communications
Volume	7
DOIs	https://doi.org/10.1038/ncomms10374
Publication status	Published - 19 Jan 2016

Keywords

Photonics

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Cite this

@article{b33be9818bfa41cf9cfc1611723ec224,

title = "Bioabsorbable polymer optical waveguides for deep-tissue photomedicine",

abstract = "Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.",

keywords = "Photonics",

author = "Sedat Nizamoglu and Gather, {Malte Christian} and Matja{\v z} Humar and Myunghwan Choi and Seonghoon Kim and Kim, {Ki Su} and Hahn, {Sei Kwang} and Giuliano Scarcelli and Mark Randolph and Redmond, {Robert W.} and Yun, {Seok Hyun}",

note = "This work was funded by the U.S. National Institutes of Health (R21EB013761, P41EB015903, R01CA192878), Department of Defense (FA9550-13-1-0068), Bullock-Wellman Fellowships, Marie Curie Career Integration Grant (631679), Marie Curie International Outgoing Fellowship No. 627274 within the 7th European Community Framework Programme, Human Frontier Science Program (Young Investigator Grant RGY0074/2013), the Bio & Medical Technology Development Program of the National Research Foundation of Korea (2012M3A9C6049791) and the IT Consilience Creative Program of MKE and NIPA (IITP-2015-R0346-15-1007).",

year = "2016",

month = jan,

day = "19",

doi = "10.1038/ncomms10374",

language = "English",

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journal = "Nature Communications",

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T1 - Bioabsorbable polymer optical waveguides for deep-tissue photomedicine

AU - Nizamoglu, Sedat

AU - Gather, Malte Christian

AU - Humar, Matjaž

AU - Choi, Myunghwan

AU - Kim, Seonghoon

AU - Kim, Ki Su

AU - Hahn, Sei Kwang

AU - Scarcelli, Giuliano

AU - Randolph, Mark

AU - Redmond, Robert W.

AU - Yun, Seok Hyun

N1 - This work was funded by the U.S. National Institutes of Health (R21EB013761, P41EB015903, R01CA192878), Department of Defense (FA9550-13-1-0068), Bullock-Wellman Fellowships, Marie Curie Career Integration Grant (631679), Marie Curie International Outgoing Fellowship No. 627274 within the 7th European Community Framework Programme, Human Frontier Science Program (Young Investigator Grant RGY0074/2013), the Bio & Medical Technology Development Program of the National Research Foundation of Korea (2012M3A9C6049791) and the IT Consilience Creative Program of MKE and NIPA (IITP-2015-R0346-15-1007).

PY - 2016/1/19

Y1 - 2016/1/19

N2 - Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.

AB - Advances in photonics have stimulated significant progress in medicine, with many techniques now in routine clinical use. However, the finite depth of light penetration in tissue is a serious constraint to clinical utility. Here we show implantable light-delivery devices made of bio-derived or biocompatible, and biodegradable polymers. In contrast to conventional optical fibres, which must be removed from the body soon after use, the biodegradable and biocompatible waveguides may be used for long-term light delivery and need not be removed as they are gradually resorbed by the tissue. As proof of concept, we demonstrate this paradigm-shifting approach for photochemical tissue bonding (PTB). Using comb-shaped planar waveguides, we achieve a full thickness (>10 mm) wound closure of porcine skin, which represents ~10-fold extension of the tissue area achieved with conventional PTB. The results point to a new direction in photomedicine for using light in deep tissues.

KW - Photonics

U2 - 10.1038/ncomms10374

DO - 10.1038/ncomms10374

M3 - Article

SN - 2041-1723

VL - 7

JO - Nature Communications

JF - Nature Communications

M1 - 10374

ER -

Bioabsorbable polymer optical waveguides for deep-tissue photomedicine

Abstract

Keywords

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