Best practice considerations for using the selectivity factor, s, as a metric for the efficiency of kinetic resolutions

Mark D. Greenhalgh, James E. Taylor, Andrew D. Smith

Research output: Contribution to journalArticlepeer-review

23 Citations (Scopus)
9 Downloads (Pure)

Abstract

The suitability of using the selectivity factor, s, as a reaction metric for kinetic resolution reactions and the errors associated with its measurement are considered. Investigation of the analytical error associated with HPLC analysis of a kinetic resolution reveals that one of the largest potential sources of variation arises from the ability of a practitioner to integrate the peaks from a single analysis. The consequences of this error on the reliability of reported s values are discussed, and some general rules for good practice regarding the use and reporting of s as a metric are suggested.
Original languageEnglish
Pages (from-to)5554-5560
Number of pages7
JournalTetrahedron
Volume74
Issue number38
Early online date25 May 2018
DOIs
Publication statusPublished - 20 Sept 2018

Keywords

  • Kinetic resolution
  • Selectivity factor
  • Data analysis
  • Error calculations
  • HPLC analysis

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