Avascular growth, angiogenesis and vascular growth in solid tumours: the mathematical modelling of the stages of tumour development

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Abstract

The growth and development of solid tumours occurs in two distinct stages?the avascular growth phase and the vascular growth phase. During the former growth phase the tumour remains in a diffusion-limited, dormant state of a few millimetres in diameter (cf. multicell spheroids, carcinoma in situ) while during the latter growth phase, invasion and metastasis may take place. In order to accomplish the transition from avascular to vascular growth, solid tumours may secrete diffusible substances known as tumour angiogenesis factors (TAF) into the surrounding tissue. Endothelial cells which form the lining of neighbouring blood vessels respond to this chemotactic stimulus in a well-ordered sequence of events. Capillary sprouts are formed which migrate towards the tumour, eventually penetrating it and permitting vascular growth to take place. This paper will present several mathematical models which deal with the various stages of growth and development of solid tumours.
Original languageEnglish
Pages (from-to)47-87
Number of pages41
JournalMathematical and Computer Modelling
Volume23
Issue number6
DOIs
Publication statusPublished - 1996

Keywords

  • Avascular growth
  • Tumour angiogenesis
  • Vascular growth
  • Mathematical modelling

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